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05.03.2021 | Sleep Breathing Physiology and Disorders • Original Article

Levels of trace blood elements associated with severe sleep disturbance in maintenance hemodialysis patients

verfasst von: Shilin Xu, De’e Zou, Ruiying Tang, Shuting Li, Wenxuan Chen, Luona Wen, Yun Liu, Yan Liu, Xiaoshi Zhong

Erschienen in: Sleep and Breathing | Ausgabe 4/2021

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Abstract

Purpose

Sleep disturbance is frequently observed in patients on maintenance hemodialysis (MHD), and this population usually presents imbalances in trace elements. We investigated the association between blood trace element levels and sleep quality in patients on MHD.

Methods

This cross-sectional and single-center study was performed in September 2019. Patients regularly undergoing hemodialysis for > 3 months at our center were recruited, and demographic, clinical, and laboratory parameters were recorded. The Pittsburgh Sleep Quality Index (PSQI) was applied to define sleep disturbance. Blood trace element (zinc, manganese, copper, selenium, and lead) levels were measured using an inductively coupled plasma mass spectrometer.

Results

In total, 121 patients on MHD (male/female = 68:53) were enrolled in the study (mean age 63.7 ± 13.9 years, median dialysis vintage 38.0 [20.0, 60.0] months). According to PSQI, 56 (46%) patients experienced severe sleep disturbance. These patients were characterized by older age, higher serum parathyroid hormone levels, and lower blood selenium levels (all P < 0.05). No significant differences in blood zinc, manganese, copper, and lead levels were observed between groups. Univariate binary logistic regression showed that lower blood selenium levels were associated with severe sleep disturbance (odds ratio = 0.976, 95% confidence interval: 0.954–0.999, P = 0.038). Multivariate analyses also confirmed the results after adjusting for confounding factors.

Conclusion

Our study indicated an association between lower blood selenium levels and the occurrence of severe sleep disturbances in patients on MHD. However, a prospective study with a larger sample size and assessing the importance of selenium supplementation are needed to confirm the results.

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Titel: Levels of trace blood elements associated with severe sleep disturbance in maintenance hemodialysis patients
verfasst von: Shilin Xu
De’e Zou
Ruiying Tang
Shuting Li
Wenxuan Chen
Luona Wen
Yun Liu
Yan Liu
Xiaoshi Zhong
Publikationsdatum: 05.03.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2021
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02336-w

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Levels of trace blood elements associated with severe sleep disturbance in maintenance hemodialysis patients

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