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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Cancer 1/2017

Life tables for global surveillance of cancer survival (the CONCORD programme): data sources and methods

Zeitschrift:
BMC Cancer > Ausgabe 1/2017
Autoren:
Devon Spika, Finian Bannon, Audrey Bonaventure, Laura M Woods, Rhea Harewood, Helena Carreira, Michel P Coleman, Claudia Allemani
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12885-017-3117-8) contains supplementary material, which is available to authorized users.

Abstract

Background

We set out to estimate net survival trends for 10 common cancers in 279 cancer registry populations in 67 countries around the world, as part of the CONCORD-2 study. Net survival can be interpreted as the proportion of cancer patients who survive up to a given time, after eliminating the impact of mortality from other causes (background mortality). Background mortality varies widely between populations and over time. It was therefore necessary to construct robust life tables that accurately reflected the background mortality in each of the registry populations.

Methods

Life tables of all-cause mortality rates by single year of age and sex were constructed by calendar year for each population and, when possible, by racial or ethnic sub-groups. We used three different approaches, based on the type of mortality data available from each registry. With death and population counts, we adopted a flexible multivariable modelling approach. With unsmoothed mortality rates, we used the Ewbank relational method. Where no data were available from the registry or a national statistical office, we used the abridged UN Population Division life tables and interpolated these using the Elandt-Johnson method. We also investigated the impact of using state- and race-specific life tables versus national race-specific life tables on estimates of net survival from four adult cancers in the United States (US).

Results

We constructed 6,514 life tables covering 327 populations. Wide variations in life expectancy at birth and mortality by age were observed, even within countries. During 1995–99, life expectancy was lowest in Nigeria and highest in Japan, ranging from 47 to 84 years among females and 46 to 78 years among males. During 2005–09, life expectancy was lowest in Lesotho and again highest in Japan, ranging from 45 to 86 years among females and 45 to 80 years among males. For the US, estimates of net survival differed by up to 4% if background mortality was fully controlled with state- and race-specific life tables, rather than with national race-specific life tables.

Conclusions

Background mortality varies worldwide. This emphasises the importance of using population-specific life tables for geographic and international comparisons of net survival.
Zusatzmaterial
Additional file 1: Additional information on the selection of knot locations for the flexible Poisson model. (DOCX 18 kb)
12885_2017_3117_MOESM1_ESM.docx
Additional file 2: Model for constructing race/ethnic-specific life tables using a continuous interaction term between race and age. (DOCX 13 kb)
12885_2017_3117_MOESM2_ESM.docx
Additional file 3: Example of a life table report. (PDF 38 kb)
12885_2017_3117_MOESM3_ESM.pdf
Additional file 4: Background mortality in 327 populations covered by 279 registries during 1995–2009: mean life expectancy at birth (years), infant mortality rate per 1,000 live births, childhood mortality rate per 1,000 live births, and probabilities (%) of dying between exact ages 15 and 60 years, 60 and 85 years, and 85 and 99 years, by sex and calendar period. (XLS 386 kb)
12885_2017_3117_MOESM4_ESM.xls
Additional file 5: Alternative model for constructing race/ethnic-specific life tables using dummy interaction terms. (DOCX 16 kb)
12885_2017_3117_MOESM5_ESM.docx
Literatur
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