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Erschienen in: Cancer Immunology, Immunotherapy 11/2014

01.11.2014 | Letter to the Editors

Limited efficacy of intratumoral IL-2 applied to large melanoma metastases

verfasst von: Benjamin Weide, Thomas Kurt Eigentler, Giuliano Elia, Dario Neri, Claus Garbe

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 11/2014

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Excerpt

Dear Editors, …
Literatur
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Zurück zum Zitat Weide B, Eigentler TK, Pflugfelder A, Leiter U, Meier F, Bauer J, Schmidt D, Radny P, Pfohler C, Garbe C (2011) Survival after intratumoral interleukin-2 treatment of 72 melanoma patients and response upon the first chemotherapy during follow-up. Cancer Immunol Immunother 60(4):487–493. doi:10.1007/s00262-010-0957-3 PubMedCrossRef Weide B, Eigentler TK, Pflugfelder A, Leiter U, Meier F, Bauer J, Schmidt D, Radny P, Pfohler C, Garbe C (2011) Survival after intratumoral interleukin-2 treatment of 72 melanoma patients and response upon the first chemotherapy during follow-up. Cancer Immunol Immunother 60(4):487–493. doi:10.​1007/​s00262-010-0957-3 PubMedCrossRef
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Zurück zum Zitat Weide B, Eigentler TK, Pflugfelder A, Zelba H, Martens A, Pawelec G, Giovannoni L, Ruffini PA, Elia G, Neri D, Gutzmer R, Becker JC, Garbe C (2014) Intralesional treatment of Stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunological responses. Cancer Immunol Res. doi:10.1158/2326-6066.cir-13-0206 Weide B, Eigentler TK, Pflugfelder A, Zelba H, Martens A, Pawelec G, Giovannoni L, Ruffini PA, Elia G, Neri D, Gutzmer R, Becker JC, Garbe C (2014) Intralesional treatment of Stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunological responses. Cancer Immunol Res. doi:10.​1158/​2326-6066.​cir-13-0206
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Zurück zum Zitat Weide B, Derhovanessian E, Pflugfelder A, Eigentler TK, Radny P, Zelba H, Pfohler C, Pawelec G, Garbe C (2010) High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma. Cancer 116(17):4139–4146. doi:10.1002/cncr.25156 PubMedCrossRef Weide B, Derhovanessian E, Pflugfelder A, Eigentler TK, Radny P, Zelba H, Pfohler C, Pawelec G, Garbe C (2010) High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma. Cancer 116(17):4139–4146. doi:10.​1002/​cncr.​25156 PubMedCrossRef
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Zurück zum Zitat Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K, Abrams J, Sznol M, Parkinson D, Hawkins M, Paradise C, Kunkel L, Rosenberg SA (1999) High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 17(7):2105–2116PubMed Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K, Abrams J, Sznol M, Parkinson D, Hawkins M, Paradise C, Kunkel L, Rosenberg SA (1999) High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 17(7):2105–2116PubMed
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Zurück zum Zitat Schwager K, Hemmerle T, Aebischer D, Neri D (2013) The immunocytokine L19-IL2 eradicates cancer when used in combination with CTLA-4 blockade or with L19-TNF. J Invest Dermatol 133(3):751–758. doi:10.1038/jid.2012.376 PubMedCrossRef Schwager K, Hemmerle T, Aebischer D, Neri D (2013) The immunocytokine L19-IL2 eradicates cancer when used in combination with CTLA-4 blockade or with L19-TNF. J Invest Dermatol 133(3):751–758. doi:10.​1038/​jid.​2012.​376 PubMedCrossRef
Metadaten
Titel
Limited efficacy of intratumoral IL-2 applied to large melanoma metastases
verfasst von
Benjamin Weide
Thomas Kurt Eigentler
Giuliano Elia
Dario Neri
Claus Garbe
Publikationsdatum
01.11.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Cancer Immunology, Immunotherapy / Ausgabe 11/2014
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-014-1584-1

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