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Journal of Clinical Monitoring and Computing

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02.05.2023 | Review

Linear thinking does not reflect the newer 21st-century anesthesia concepts. A narrative review

verfasst von: Pablo O. Sepúlveda, Rodrigo Vera, M. Silvia Fernández, Francisco A. Lobo

Erschienen in: Journal of Clinical Monitoring and Computing | Ausgabe 5/2023

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Abstract

The brain constitutes a good example of a chaotic, nonlinear biological system where large neuronal networks operate chaotically with random connectivity. This critical state is significantly affected by the anesthetic loss of consciousness induced by drugs whose pharmacological behavior has been classically based on linear kinetics and dynamics. Recent developments in pharmacology and brain monitoring during anesthesia suggest a different view that we tried to explore in this article. The concepts of effect-site for hypnotic drugs modeling a maximum effect, electroencephalographic dynamics during induction, maintenance, and recovery from anesthesia are discussed, integrated into this alternative view, and how it may be applied in daily clinical practice.

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Titel: Linear thinking does not reflect the newer 21st-century anesthesia concepts. A narrative review
verfasst von: Pablo O. Sepúlveda
Rodrigo Vera
M. Silvia Fernández
Francisco A. Lobo
Publikationsdatum: 02.05.2023
Verlag: Springer Netherlands
Erschienen in: Journal of Clinical Monitoring and Computing / Ausgabe 5/2023
Print ISSN: 1387-1307
Elektronische ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-023-01021-5

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