Notes
Antiviral Activity of Selected Catharanthus Alkaloids

https://doi.org/10.1002/jps.2600571235Get rights and content

Abstract

Thirty-six alkaloids isolated either from Catharanthus roseus or C. lanceus were evaluated for in vitro activity against vaccinia and polio type III viruses. Nine of these alkaloids were effective as antiviral agents, with pericalline being the most effective.

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    The author wishes to express his indebtedness to Dr. E. M. Van Heyningen and Dr. L. D. Hatfield for providing the compounds under investigation, and also to Mr. T. E. Cole for the amino acid analyzer assays provided.

    *

    Eli Lilly and Co., Indianapolis, IN 46206.

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