Regular ArticleDifferential Catalytic Efficiency of Allelic Variants of Human GlutathioneS-Transferase Pi in Catalyzing the Glutathione Conjugation of Thiotepa☆,☆☆
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Activity of glutathione S-transferase and its π isoenzyme in the context of single nucleotide polymorphism in the GSTP1 gene (rs1695) and tobacco smoke exposure in the patients with acute pancreatitis and healthy subjects
2021, Biomedicine and PharmacotherapyCitation Excerpt :The GG genotype resulting in the substitution of Ile with Val in the 105 site of polypeptide chain causes a steric change at the substrate-binding site of the enzyme. Altered conformation of the substrate-binding site(s) may contribute to final substrate specificities [34,36]. It can explain a slight increase in GSH concentration as a substrate for this enzyme.
Responses of cytochrome P450, GST and MXR in the mussel Perna viridis to the exposure of Aureococcus anophagefferens
2020, Marine Pollution BulletinCitation Excerpt :Taken all together, we proposed that A. anophagefferens could induce oxidative stress in gills, but not at the oxidative damage level, and that GST could play an important role in protecting cells from oxidative stress. As for the decrease in GST-π expression at 12 h after exposure to A. anophagefferens, it could be resulted from the inhibition of metabolites mediated by CYP450 enzymes or accumulation of GSH conjugation with chemicals in A. anophagefferens on GST expression (Egaas et al., 1999; Srivastava et al., 1999). Accordantly, Fu and Xie (2006) reported that transcription of GST-α, GST-ρ and mGST3 isoforms were up-regulated at 6 h, but decreased at 12–24 h post injection of MC-LR in liver of the common carp Cyprinus carpio L.
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This investigation was supported in part by Grants ES 09140 (to S.V.S.) and ES 07804 (to P.Z.) from the National Institute of Environmental Health Sciences (NIEHS), NIH, and Grant CA 27967 (to Y.C.A.) from the National Cancer Institute (NCI), NIH, and its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS or NCI.
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Ozols, R. F.
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