Biochemical and Biophysical Research Communications
Volume 200, Issue 3, 15 May 1994, Pages 1440-1448
Regular ArticleSphingolipid Activator Protein D (sap-D) Stimulates the Lysosomal Degradation of Ceramide in Vivo
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Cited by (135)
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2022, Advanced Drug Delivery ReviewsCitation Excerpt :Saposin C deficiency results in GD [84,85]. Saposin D is involved in the hydrolysis of ceramide by ceramidase, impaired in Farber disease [86,87]. Cleavage of saposin C from prosaposin depends on Cathepsin D [88].
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2018, Progress in Molecular Biology and Translational ScienceCitation Excerpt :It catalyzes the degradation of ceramide to sphingosine and fatty acid. In vivo, the enzyme requires the presence of Sap D.327 Patients with Farber disease develop painful and progressive joint deformations, subcutaneous nodules (lipogranulomas), and progressive hoarseness. The four saposins A–D arise from a common precursor protein, the prosaposin.
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