Biochemical and Biophysical Research Communications
Regular ArticleIdentification of Cell Surface Binding Sites for PC-Cell-Derived Growth Factor, PCDGF, (Epithelin/Granulin Precursor) on Epithelial Cells and Fibroblasts☆,☆☆
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2003, Biochemical and Biophysical Research CommunicationsCitation Excerpt :These data show that expression of PCDGF/GP88 in cancer cells plays a critical role in tumor formation. Even though putative high affinity receptors for the PCDGF/GP88 precursor, TGF-e or the 6 kDa epithelins have only been partially characterized [14,20,21], signaling pathway leading to stimulation of proliferation has been examined only for the 88 kDa growth factor in fibroblasts, adrenal carcinoma cells, breast cancer cells, ovarian cancer cells, and multiple myelomas [22–27]. For all cell types, the growth factor activated mitogen-activated protein kinase (MAP kinase Erk1/2) as well as phosphatidylinositol 3′-kinase (PI-3 kinase) pathways leading to the stimulation of several cyclins including Cyclin D1 and Cyclin B [22,23,25,26].
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This work was supported by Grant RO1CA 55439 from the National Institutes of Health and by Grant DAMD17-96-1-6072 from the U.S. Army.
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Abbreviations used: BSA, bovine serum albumin; DME, Dulbecco's modified Eagle's medium; DSS, disuccinimidyl suberate; EGF, epidermal growth factor; FBS, fetal bovine serum; PAGE, polyacrylamide gel electrophoresis; PBS, phosphate-buffered saline; PCDGF, PC cell-derived growth factor
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