Regular ArticleHuman Mesenchymal Stem Cells Persist, Demonstrate Site-Specific Multipotential Differentiation, and Are Present in Sites of Wound Healing and Tissue Regeneration after Transplantation into Fetal Sheep☆
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2018, Small Ruminant ResearchCitation Excerpt :Variability in culture characteristics affects the cellular differentiation, which could be attributable to the available micro-environment. In utero transplantation of autologous or xenogenic MSCs in ovine model led to their site-specific differentiation even after development of immune system in the foetus (Liechty et al., 2000; Mackenzie and Flake, 2001; Shaw et al., 2011), which supports the role of local milieu in cellular differentiation and indicates the possibility of lack of the cell immunogenicity in ovine MSCs. Homing of the oMSCs to wounded or regenerating tissues conformed to the established characteristics of the species specific MSCs (Mackenzie and Flake, 2001).
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Communicated by M. Lichtman, M.D., 05/08/01
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Correspondence and reprint requests to: Alan W. Flake, The Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104. Fax: (215) 590-3324. E-mail: [email protected].