Abstract
A biological setpoint for fatness has been proposed in the medical literature. This body weight setpoint functions as a point of stable equilibrium. In an underfed state, with resulting weight loss, the body will reduce the relative energy expenditure by metabolic adaption which reduces the rate of weight loss. Previous mathematical models of energy expenditure and weight loss dynamics have not addressed this setpoint mechanism. The setpoint model has been proposed to quantify this biological process and is unique in predicting energy expenditure during weight loss as a function of the setpoint fat-free mass ratio and setpoint energy expenditure, eliminating the various controlling characteristics such as age, gender and heredity. The model is applied to the seminal Minnesota human semistarvation experiment and is used to predict weight vs time on an individual basis and the caloric requirements for weight maintenance at the reduced weight. Comparison is made with the Harris-Benedict equations and the Brody-Kleiber. (W 3/4) law.
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References
Cunningham, J. J. (1991). Body composition as a determinant of energy expenditure: a synthetic review and a proposed general prediction equation. Am. J. Clin. Nutr. 54, 963–969.
Finer, N., P. C. Swan and F. T. Mitchell (1986). Sustained depression of the resting metabolic rate after massive weight loss. Clin. Sci. 70, 395–398.
Foster, G. D. et al. (1995). The energy cost of walking before and after significant weight loss. Med. Sci. Sports Exerc. 27, 888–894.
Garner, D. M. (1997). Handbook of Treatments for Eating Disorders, 2nd edn, D. M. Garner and P. E. Garfinkel (Eds), New York: Guilford Press, pp. 149–150.
Harris, J. A. and F. G. Benedict (1919). A Biometric Study of Basal Metabolism in Man, Washington (DC): Carnegie Institute of Washington.
Keys, A. (1950). The Biology of Human Starvation, University of Minn Press.
Kleiber, M. (1975). The Fire of Life: An Introduction to Animal Energetics, Robert E. Kreiger Co.
Kozusko, F. P. (1999). A setpoint based dieting model. Math Comput Model. 29, 1–7.
Leibel, R. L. (1990). Is obesity due to a heritable difference in ’set point’ for adiposity? West. J. Med. 153, 429–431.
Leibel, R. L., M. Rosenbaum and J. Hirsch (1995). Changes in energy expenditure resulting from altered body weight. N. Engl. J. Med. 332, 621–628.
Luke, A. and D. A. Schoeller (1992). Basal metabolic rate, fat-free mass, and body cell mass during energy restriction. Metabolism 41, 450–456.
Mifflin, M. D. et al. (1990). A new predictive equation for resting energy expenditure in healthy individuals. Am. J. Clin. Nutr. 51, 241–247.
Taylor, H. L. and A. Keys (1950). Adaption to caloric restriction. Science 112, 215–218.
Van der Walt, W. H. and C. H. Wyndham (1973). An equation for prediction of energy expenditure of walking and running. J. Appl. Physiol. 34, 559–563.
Weigle, D. S. (1988). Contribution of decreased body mass to diminished thermic effect of exercise in reduced obese men. Int. J. Obes. 12, 567–578.
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Kozusko, F.P. Body weight setpoint, metabolic adaption and human starvation. Bull. Math. Biol. 63, 393–403 (2001). https://doi.org/10.1006/bulm.2001.0229
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DOI: https://doi.org/10.1006/bulm.2001.0229