Regular ArticleCD200 Immunoadhesin Suppresses Collagen-Induced Arthritis in Mice
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2019, Journal of AutoimmunityRole of the CD200-CD200R Axis During Homeostasis and Neuroinflammation
2019, NeuroscienceCitation Excerpt :Likewise, in cultured retinal myeloid cells from CD200-deficient mice with experimental autoimmune uveoretinitis (EAU), an augmented NO-microglial production was detected on IFNγ addition (Copland et al., 2007). Another experimental test showing more data on the effect of CD200 revealed that activation of CD200R1 with CD200Fc –a soluble recombinant immunoadhesin frequently used to activate CD200R (Gorczynski et al., 2001a; 2001b)–, in LPS-stimulated retinal microglial cultures, inhibits the production of pro-inflammatory mediators through a decrease in the transcription of NF-κB (Copland et al., 2007; Costello et al., 2011; Denieffe et al., 2013; Jiang et al., 2016). Moreover, a recent report demonstrated that the addition of CD200 to microglial cultures exposed to MPP+ (1-methyl-4-phenylpyridinium) inhibited ATP release (Ren et al., 2016).
A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo
2018, Molecular Therapy Nucleic AcidsCell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment
2018, Leukemia ResearchCitation Excerpt :It is apparent that gene-specific siRNAs for POTEA led to attenuation of expression of this TF, and simultaneously to decreased proliferation in treated CLL cells. There are now abundant studies which have documented a role for the CD200:CD200R axis in regulation of inflammation, acquired immunity and cancer biology [1,17,18]. Based on the structure of CD200, with a prominent extracellular V + C domain, a small transmembrane domain with no signaling motifs and no docking sites for adapter signaling molecules, and a short cytoplasmic tail lacking signaling motifs, it had been prevailing dogma that signaling by CD200 occurred through engagement of its extracellular V + C region with a receptor (CD200R) present on other cells [19].
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