Regular ArticleIn Vivo Destruction of Tumor Tissue by Cryoablation Can Induce Inhibition of Secondary Tumor Growth: An Experimental Study☆
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Treatment of Hepatocellular Carcinoma by Multimodal In Situ Vaccination Using Cryoablation and a Plant Virus Immunostimulant
2023, Journal of Vascular and Interventional RadiologyImmunomodulatory effects of ablation therapy on tumors: Potentials for combination with immunotherapy
2020, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :However, these DCs have a poor tumor-killing effect in vivo, and only retard the growth of re-challenged tumors. The frequency of cryoablation has been reported to affect tumor growth and local T cell recruitment, as well as immune activation or immunosuppression after cryoablation [59–62]. A previous study [63] analyzed the immune activation effect of cryoablation by regulating the freezing rate in a mouse breast cancer model.
Interventional therapy combined with radiotherapy for pancreatic carcinoma
2020, Integrative Pancreatic Intervention Therapy: A Holistic ApproachPercutaneous ablative cryoimmunotherapy for micrometastaic abscopal effect: No complications
2018, CryobiologyCitation Excerpt :Cryoablation has a beneficial immunogenic profile compared with other ablative techniques due to the propensity to induce a high necrosis/apoptosis ratio, disrupting the cellular membrane while leaving TAAs intact; which would be degraded to a higher extent by thermal techniques [1]. Furthermore, cryoablation has been demonstrated to induce statistically significant reductions in secondary tumor growth and propensity for pulmonary metastasis in a mouse model, due to its ability to expose TAAs that have previously evaded immunosurveillance [10]. Combination cryoablation with adjuvant pharmacologic induction of the tumor-specific immune response showed enhanced tumor rejection as well as increased intratumoral cytotoxic (CD8) TIL activity [16].
Systemic antitumor immune response following reconstruction using frozen autografts for total en bloc spondylectomy
2014, Spine JournalCitation Excerpt :The tumor antigens released from the necrotic tumor cells in tumor-bearing grafted bone inside the cage activate the tumor-specific immune response. Previous reports have suggested immune system activation brought about by cryosurgery [4,5,8,9]. Nishida et al. [10] reported that reimplantation of tumor tissue frozen using liquid nitrogen induces antitumor activity against murine osteosarcoma and the serum levels of INF-γ and IL-12 increased after treatment [11].
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This work was funded by institutional sources.