Regular articleCYTOKINES AND GLUCOCORTICOIDS MODULATE HUMAN BRONCHIAL EPITHELIAL CELL PEPTIDASES
References (0)
Cited by (43)
Temporal changes in neutral endopeptidase/CD10 immunoexpression in the cyclic and early pregnant canine endometrium
2014, TheriogenologyCitation Excerpt :CD10 functions as a cell-surface enzyme acting to reduce the cell response to some peptide factors, including oxytocin, endothelins, and interleukin 1 [12]; through cleavage and inactivation of these peptides, NEP/CD10 reduces its local concentrations and decreases their effects [13-15]. NEP/CD10 has been implicated in the regulation of growth and differentiation in many cellular systems, in which it plays an important role in the maintenance of homeostasis [16–18] and in carcinogenesis and tumor progression [19–23], possibly mediated through its role on angiogenesis [24], in cell cycle activity [25], and apoptosis [26]. In human, NEP/CD10 is frequently used as a reliable immunohistochemical marker of normal endometrial stroma [27,28] and is used for diagnosis of several neoplasic [28–30] and non-neoplasic [31,32] gynecological conditions.
Noradrenaline deficiency in brain increases β-amyloid plaque burden in an animal model of Alzheimer's disease
2007, Neurobiology of AgingCitation Excerpt :Changes in NEP expression have also been reported in response to several inflammatory mediators. In a bronchial epithelial cell line, IL1β, and to a lesser extent TNFα, increased NEP protein expression while IFNγ decreased it [45]. Interestingly, in the same study NEP expression was increased by the cAMP analog dbcAMP, while incubation with a phosphodiesterase inhibitor potentiated the increase due to IL1β.
Multiple androgen response elements cooperate in androgen regulated activity of the type 1 neutral endopeptidase promoter
2006, Molecular and Cellular EndocrinologyAscorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells
2005, Regulatory Peptides
- f1
Correspondence to: V.H.J. van der Velden, Department of Immunology, Erasmus Univesity Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands: E-mail: [email protected]
- f2
Phone: 0171-2674466
- f3
Phone: 0171-2674466