Elsevier

Cytokine

Volume 18, Issue 6, June 2002, Pages 340-343
Cytokine

Short Communications
IL-6 AND LIPOPROTEIN (a) [LP(a)] CONCENTRATIONS ARE RELATED ONLY IN PATIENTS WITH HIGH APO(a) ISOFORMS IN MONOCLONAL GAMMOPATHY

https://doi.org/10.1006/cyto.2002.1044Get rights and content

Abstract

We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy subjects. No significant differences in Lp(a) levels and distribution of subjects with different sizes of apo(a) isoforms were found between patients and healthy controls. Relationship between IL-6 and Lp(a) levels was strongly dependent on the size of apo(a) isoforms. In patients with high-size apo(a) isoforms Lp(a) levels positively correlated (r=0.475, P=0.0007) to IL-6 concentrations, whereas no correlation was found in patients with low apo(a) isoforms. Our present finding may provide a plausible explanation for the contradictory findings about the acute phase protein nature of Lp(a).

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Correspondence to: Dr George Füst, 3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Kútvölgyi út 4, H-1125, Hungary. Tel:/Fax: 361-212-9351; E-mail: [email protected]

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