Regular ArticleActivation-Induced Expression of Human Programmed Death-1 Gene in T-Lymphocytes
References (15)
- et al.
J. Exp. Med.
(1983) - et al.
J. Immunol.
(1993) - et al.
Biochem. J.
(1995) - et al.
Science
(1995) - et al.
EMBO J.
(1992) - L. R. Finger, J. Pu, R. Wasserman, R. Vibhakar, E. Louie, R. R. Hardy, P. D. Burrows, L. G. Billips,...
- et al.
Genomics
(1994)
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