Regular articlePredominance of MMP-1 and MMP-2 in Epiretinal and Subretinal Membranes of Proliferative Vitreoretinopathy
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Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: Correlation with extent, duration of RRD and PVR grade
2012, CytokineCitation Excerpt :Increased expression of the matrix metalloproteinase (MMP) proMMP-2, proMMP-9 (latent forms) and MMP-9 has also been observed in the vitreous in the context of RRD [14,15] while stromelysin-1 (MMP-3), has been reported to be present in the majority of epi- and subretinal membranes during PVR [16–18]. Loss of balance between MMP and tissue inhibitors of metalloproteinase (TIMP) activity is a key feature of the pathophysiology of several diseases [19–21] including PVR [15,16]. It has been shown that epi- and subretinal PVR membranes stain positive for TIMP-1 and that TIMP-1 is detected in the SRF and vitreous in cases of RRD complicated by PVR [13,15].
Pathophysiology of ocular trauma
2012, Retina Fifth EditionAdipokine levels in subretinal fluid from patients with rhegmatogenous retinal detachment
2012, Experimental Eye ResearchCitation Excerpt :Not surprisingly, an altered expression of TIMP-1 is believed to play a role in ocular fibrosis. RPE cells, among other cells, have been shown to produce TIMP-1 in vitro (Alexander et al., 1990), and TIMP-1 has been demonstrated in epiretinal and subretinal membranes (Webster et al., 1999). Moreover, elevated vitreous TIMP-1 levels were associated with PVR development (Matsuo et al., 1998).
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Corresponding author: Dr. G.A. Limb, Dept. of Pathology, Institute of Ophthalmology, Bath Street, London, EC1V 9EL, U.K.