Clinical Paperoral Medicines
Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery

https://doi.org/10.1006/ijom.2003.0515Get rights and content

Abstract

The objective of this study was to compare the analgesic efficacy of a single-dose of preoperative intravenous tramadol versus ketorolac in preventing pain after third molar surgery. Sixty-four patients undergoing elective third molar surgery were randomly assigned into one of the two groups (32 in each group): Group I received tramadol 50 mg, and Group 2 received ketorolac 30 mg intravenously preoperatively before the surgery. After injection of the study drugs, a standard intravenous sedation technique was administered and the impacted third molars were removed under local anaesthetic. The difference in postoperative pain was assessed by four primary end-points: pain intensity as measured by a 100-mm visual analogue scale hourly for 12 h, median time to rescue analgesic, postoperative acetaminophen consumption, and patient's global assessment. Throughout the 12-h investigation period, patients reported significantly lower pain intensity scores in the ketorolac versus tramadol group (P=0.05, Mann–Whitney U-test). Patients also reported significantly longer median time to rescue analgesic (9.0 h versus 7.0 h, P=0.007, log rank test), lesser postoperative acetaminophen consumption (P=0.02, Mann–Whitney U-test) and better global assessment (P=0.01, χ2 test) for the ketorolac versus tramadol group. Preoperative intravenous ketorolac 30 mg is more effective than tramadol 50 mg in the prevention of postoperative dental pain.

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Cited by (46)

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    2014, British Journal of Oral and Maxillofacial Surgery
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    The results for vomiting were similar in the 2 groups. We used specific inclusion and exclusion criteria to select only those studies that compared single-dose tramadol and NSAID in operations on the third molars, and all of those studies that were available in the databases were evaluated.3–12 This work used only the information from studies with a score of 3 or more on the Oxford Quality Scale so that we assessed only the best quality studies.3–6,10

  • Comparative study of intravenous Tramadol versus Ketorolac for preventing postoperative pain after third molar surgery - A prospective randomized study

    2014, Journal of Cranio-Maxillofacial Surgery
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    Intravenous Ketorolac is better than Tramadol when given preoperatively in preventing the postoperative third molar surgical pain (Ong and Tan, 2004). The median analgesic duration was 9 h, whereas for intravenous Tramadol was 7 h, where the analgesic effect of the drug is reduced at the time when postoperative pain is in its peak (Ong and Tan, 2004). In our study, the median analgesic duration for Ketorolac and Tramadol was 10 and 7 h and was statistically significant.

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