Regular ArticleFamilial Primary Biliary Cirrhosis in Hiroshima
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Cited by (99)
Primary Biliary Cholangitis: Pathophysiology
2024, Clinics in Liver DiseasePrimary Biliary Cholangitis in Males: Pathogenesis, Clinical Presentation, and Prognosis
2022, Clinics in Liver DiseaseCitation Excerpt :Portal inflammatory cell infiltrate primarily plasma cells and lymphocytes Characteristic serologic markers include:1–3,18–33,42 Increased levels of ALP
Primary biliary cholangitis: Diagnosis and treatment
2018, Liver ResearchCitation Excerpt :Familial studies of PBC in Europe and North America have suggested that genetic factors play a role in disease susceptibility. In Europe, the prevalence of PBC among people with family history of the disease is estimated to be 1%–4.5%, which is about 1000-fold higher than in the general population.19 However, familial studies are rare, especially in Asia, and those that have been conducted tend to be retrospective in design.
Primary Biliary Cholangitis
2017, Handbook of Systemic Autoimmune DiseasesUsing GWAS to identify genetic predisposition in hepatic autoimmunity
2016, Journal of AutoimmunityThe immunogenetics of primary biliary cirrhosis: A comprehensive review
2015, Journal of AutoimmunityCitation Excerpt :Sibling relative risk of the disease was calculated at 10.5 [37] in a UK series and 10.7 in the USA [38]. Numbers of individuals affected by PBC are also abnormally high in selected ethnically defined sub-populations [39,40] and in selected families within well-characterised comprehensive healthcare systems [35,41]. High throughput genetic studies have transformed our understanding of the genes conferring risk for autoimmune diseases including PBC.
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Correspondence to: M. Eric Gershwin, Division of Rheumatology and Allergy, School of Medicine, TB 192, University of California, Davis, CA 95616-8660, USA. Fax: 530-752-4669. E-mail:[email protected]