Regular ArticleInduction of Heat Shock Proteins by Tyrosine Kinase Inhibitors in Rat Cardiomyocytes and Myogenic Cells Confers Protection Against Simulated Ischemia☆
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Celastrol-type HSP90 modulators allow for potent cardioprotective effects
2019, Life SciencesCitation Excerpt :Modulation of HSP90 activity by celastrol is cardioprotective [10], nevertheless, other HSP90 modulators have conflicting results regarding cardioprotection. For instance the N-terminal modulator geldanamycin protects neonatal rat cardiomyocytes from ischemic stress following 4 h pretreatment [23], while inhibits ischemic preconditioning in vitro [17], cardiac ischemic postconditioning in vivo [24], and increases cellular damage when given at reperfusion in an ex vivo I/R model [25]. Similarly, 4 h pretreatment with radicicol protects neonatal rat cardiomyocytes from ischemia [26], yet short term (10 min) pre-treatment does not offer cardioprotection on an in vivo I/R model [27], demonstrating divergent responses of different HSP90 targeting molecules in the context of ischemia and ischemia/reperfusion injury.
Comparison of the effect of heat shock factor inhibitor, KNK437, on heat shock- and chemical stress-induced hsp30 gene expression in Xenopus laevis A6 cells
2008, Comparative Biochemistry and Physiology - A Molecular and Integrative PhysiologyRadicicol improves regeneration of skeletal muscle previously damaged by crotoxin in mice
2008, ToxiconCitation Excerpt :Furthermore, HSPs contribute to several cellular processes, such as chaperoning proteins into degradation pathways as part of the ubiquitin proteasome system, maintaining the translocation-competent folding of endoplasmic reticulum and mitocondrial precursor proteins in the cytosol, and binding newly synthesized amino acid chains to ribosomes (Pilon and Schekman, 1999). In order to address the biological effects of HSPs, a series of compounds have been developed, including the benzoquinone ansamycin antibiotics geldanamycin and hebimycin A (Morris et al., 1996; Conde et al., 1997) and a more powerful compound, the antifungal macrocyclic antibiotic radicicol (Griffin et al., 2004), which are able to either disrupt the chaperone complex or inhibit a 90 kDa heat shock protein (HSP90). These compounds induce HSP expression by binding to HSP90, which regulates heat shock factor 1 (HSF1).
Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: Role of antioxidant enzymes and heat shock protein
2005, Journal of EthnopharmacologyBGP-15 improves contractile function of regenerating soleus muscle
2018, Journal of Muscle Research and Cell Motility
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