Regular ArticleTissue Tumor Necrosis Factor mRNA Expression Following Cecal Ligation and Puncture or Intraperitoneal Injection of Endotoxin
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2001, Biochimica et Biophysica Acta - Molecular Basis of DiseaseLimits of peritoneal cytokine measurements during abdominal lavage treatment for intraabdominal sepsis
2001, American Journal of SurgeryCitation Excerpt :There were only changes in the cytokines between survivors and nonsurvivors, for serum IL-10 with higher values in the nonsurvivors before the operation (P = 0.007), for serum TNF-α with lower values in the nonsurvivors 24 hours after the operation (P = 0.02), and still significantly lower leucocytes in the nonsurvivors before the operation (0.049). It is well known from experimental studies that peritoneal mesothelial cells [7,8] as well as peritoneal macrophages [9,10] can be regarded as a profound source of different intraabdominal cytokine production. Clinical studies in spontaneous peritonitis in ambulatory peritoneal dialysis patients and in liver cirrhosis patients with infected ascites were the first reports of high levels of IL-6, IL-10, and TNF-α in the peritoneal fluid [11–13].
Endotoxin and adjunctive therapies in gram-negative sepsis
2001, Seminars in Pediatric Infectious DiseasesCitation Excerpt :What is the appropriate animal model? Infusions of endotoxin commonly are used to model sepsis and septic shock, despite the number of physiologic differences between this model and others utilizing infusions of live or killed gram-negative organisms96 or a cecal ligation and puncture model simulating peritonitis.97,98 What are appropriate end points in clinical trials?
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