Regular ArticlesIncreased frequency of intestinal Escherichia coli carrying genes for S fimbriae and haemolysin in IgA-deficient individuals
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Gut Microbiota Perturbation in IgA Deficiency Is Influenced by IgA-Autoantibody Status
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2017, Gastroenterology Clinics of North AmericaCitation Excerpt :IgA that has undergone affinity maturation through somatic hypermutation binds to and selects for particular components of the microbiota, which leads to an increase in the diversity of the microbial community and enhances mutualism between the microbiota and the host.73 Consistent with this observation, people who are deficient in IgA have more bacteria from taxa with potentially inflammatory properties.76 Mice that are deficient in T cells owing to a lack of T-cell antigen receptor chains β and δ, as well as those that lack T follicular cells and the T-cell-dependent IgA pathway owing to T-cell-specific inactivation of the gene Bcl6 in CD4+ T cells, retain an IgA-mediated response that is specific to antigens from commensal bacteria, indicating that T-cell–independent B-cell IgA production is directed at the microbiota.77
Biological Activities of IgA
2015, Mucosal Immunology: Fourth EditionIgA Deficiency and Other Immunodeficiencies Causing Mucosal Immunity Dysfunction
2015, Mucosal Immunology: Fourth EditionDifferent phylogenetic profile and reduced mannose-sensitive adherence capacity characterize commensal Escherichia coli in IgAdeficient individuals
2013, Microbial PathogenesisCitation Excerpt :The observation that group B2 strains have a pronounced MS adherence potential is a novel finding here and this, previously unrecognized character, might contribute to their superior colonizing capacity [15]. We have previously shown that IgAd individuals had significantly increased occurrence of E. coli carrying genes for sfaD/E (S/FIC fimbriae) and hlyA (hemolysin) in their intestine compared with control individuals [18]. Here, we also found that group B2 strains from IgAd individuals more often carried the sfaD/E gene (p = 0.002) and hlyA (p = 0.02) compared with group B2 strains from control individuals.
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