Regular ArticleCombined Lesions of Perirhinal and Entorhinal Cortex Impair Rats’ Performance in Two Versions of the Spatially Guided Radial-Arm Maze☆,☆☆
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Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia
2012, Schizophrenia ResearchCitation Excerpt :The radial arm maze (RAM) (Walker and Olton, 1979) is a test of spatial learning and memory in rodents that relies on intact prefrontal (Hasselmo, 2005) and medial temporal lobe (i.e., hippocampal; (for review see Martin and Clark, 2007)) neural circuitry. Medial temporal lobe lesions produce learning and memory impairments in standard and delayed nonmatching to sample versions of the RAM in rodents (Otto et al., 1997; Liu and Bilkey, 1999). Optimal performance on the RAM also depends on communication between frontal and temporal lobe structures (Muzzio et al., 2009) since lesions in white matter connecting the hippocampus and prefrontal cortex impair RAM performance (Floresco et al., 1997).
A phase code for memory could arise from circuit mechanisms in entorhinal cortex
2009, Neural NetworksCitation Excerpt :Damage to the entorhinal cortex alone causes a transient impairment in delayed match to sample at long delays (Leonard, Amaral, Squire, & Zola-Morgan, 1995), suggesting that it normally plays a crucial role in this task until other structures can compensate. In rats, lesions of the entorhinal cortex impair spatial memory in the water maze (Steffenach, Witter, Moser, & Moser, 2005) and in the 8-arm radial maze (Otto, Wolf, & Walsh, 1997) and cause impairments of memory for odors in delayed matching tasks (Otto & Eichenbaum, 1992; Staubli, Le, & Lynch, 1995; Young, Otto, Fox, & Eichenbaum, 1997). Note that a large number of these memory impairments involve impairments in delayed matching to sample tasks with delays on the order of seconds.
The hippocampal dentate gyrus is essential for generating contextual memories of fear and drug-induced reward
2008, Neurobiology of Learning and MemoryWhen is the perirhinal cortex necessary for the performance of spatial memory tasks?
2004, Neuroscience and Biobehavioral ReviewsMemory impairment in temporal lobe epilepsy: The role of entorhinal lesions
2002, Epilepsy Research
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This research was supported by NIMH Grant R03-MH53880-01 and NSF Grant IBN9514526 to T.O. and NSF Grant IBN9514557 and a gift in memory of Colonel Norman C. Kalmar to T.J.W.
Correspondence and reprint requests should be addressed to Tim Otto. E-mail: [email protected]. Fax: (908)445-2263.
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M. BaudryJ. L. Davis, Eds.