Regular ArticlePolioviruses with Natural Recombinant Genomes Isolated from Vaccine-Associated Paralytic Poliomyelitis
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Strength in numbers: Mechanisms of viral co-infection
2019, Virus ResearchCitation Excerpt :Indeed, at a high multiplicity of infection (MOI), the poliovirus recombination frequency in cultured cells was 1.3 × 10−3, meaning that approximately one of every 1300 genomes is the product of genetic recombination (Kirkegaard and Baltimore, 1986). Recombination of poliovirus has also been observed in vivo and there is evidence of poliovirus recombination with other enteroviruses during natural infection in humans (Arita et al., 2005; Cuervo et al., 2001; Dahourou et al., 2002; Furione et al., 1993; Holmblat et al., 2014; Sergiescu et al., 1969; Simmonds and Welch, 2006). Additionally, Holmblat et al. found that defective poliovirus genomes were capable of undergoing recombination, thus restoring their fitness in vivo (Holmblat et al., 2014).
The waterborne and foodborne viral diseases related to reemerging of poliovirus
2019, Emerging and Reemerging Viral Pathogens: Volume 1: Fundamental and Basic Virology Aspects of Human, Animal and Plant PathogensVirus-Like Particles
2017, Micro- and Nanotechnology in Vaccine DevelopmentInfectious or Acquired Motor Neuron Diseases
2015, Neuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's ApproachPCR assays for the identification of rare recombination types from VP1 to 3D genomic region of vaccine derived poliovirus strains
2014, Molecular and Cellular ProbesComplete genome characterization of enterovirus 104 circulating in Northern Italy shows recombinant origin of the P3 region
2013, Infection, Genetics and EvolutionCitation Excerpt :It is known that Enterovirus evolution is promoted by both recombination and genetic drift events (Lukashev, 2005; Oberste et al., 2004a, 2004b; Simmonds and Welch, 2006). Recombination has been shown to occur among species C enteroviruses, such as poliovirus (Furione et al., 1993; Simmonds and Welch, 2006). Inter-typic recombination has been commonly observed within P2 and P3 regions rather than in the P1 region (Brown et al., 2003; Oberste et al., 2004a,b).