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BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors

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Book cover Polyomaviruses and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

BK virus (BKV), JC virus (JCV) and Simian Virus 40 (SV40) are polyomaviruses, highly homologous at the DNA and protein levels. While the human polyomaviruses BKV and JCV are ubiquitous in humans, SV40 is a simian virus which was introduced in the human population, between 1955 and 1963, by contaminated poliovaccines produced in SV40-infected monkey cells. Alternatively, SV40 or an SV40-like virus may have entered the human population before anti-poliovirus vaccination. Epidemiological evidence suggests that SV40 is now contagiously transmitted in the human population by horizontal infection, independently from the earlier contaminated poliovaccines. All three polyomaviruses transform rodent and human cells and are oncogenic in rodents. JCV induces tumors also in experimentally inoculated monkeys. Transformation and oncogenicity induced by BKV, JCV and SV40 are due to the two viral oncoproteins, the large T antigen (Tag) and the small t antigen (tag), encoded in the early region of the viral genome. Both proteins display several functions. The large Tag acts mainly by blocking the functions of p53 and pRB family tumor suppressor proteins and by inducing in host cells chromosomal aberrations and instability. The principal effect of small tag is to bind the catalytic and regulatory subunits of the protein phosphatase PP2A, thereby constitutively activating the β-catenin pathway which drives cells into proliferation. All three polyomaviruses are associated with specific human tumor types which correspond to the tumors induced by experimental inoculation of the three viruses in rodents and to the neoplasms arising in mice transgenic for the polyomavirus early region gene directed by the native viral early promoter-enhancer. Human tumors associated with BKV. JCV and SV40 contain viral DNA, generally episomic, express viral RNA and are positive for large Tag by immunohistochemistry. The low copy number of viral genomes in human tumors suggests that polyomaviruses may transform human cells by a “hit and run” mechanism. An autocrine-paracrine effect, involving secretion of growth factors by cells expressing polyomavirus Tag, may be responsible for recruiting to proliferation Tag-negative cells in polyomavirus-associated human tumors.

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References

  1. Barbanti-Brodano G, Martini F, De Mattei M et al. BK and JC human polyomaviruses and simian virus 40: natural history of infection in humans, experimental oncogenicity, and association with human tumors. Adv Virus Res 1998; 50:69–99.

    Article  PubMed  CAS  Google Scholar 

  2. Corallini A, Tognon M, Negrini M et al. Evidence for BK virus as a human tumor virus. In: Khalili K, Stoner GJ, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:431–460.

    Google Scholar 

  3. Tognon M, Corallini A, Martini F et al. Oncogenic transformation by BK virus and association with human tumors. Oncogene 2003; 22:5192–5200.

    Article  PubMed  CAS  Google Scholar 

  4. Hurault de Ligny B, Godin M, Lobbedez T et al. Virological, epidemiological and pathogenic aspects of human polyomaviruses. Presse Med 2003; 32:656–658.

    PubMed  Google Scholar 

  5. Khalili K, Del Valle L, Otte J et al. Human neurotropic polyomavirus, JCV, and its role in carcinogenesis. Oncogene 2002; 22:5181–5191.

    Article  CAS  Google Scholar 

  6. Garcea RL, Imperiale MJ. Simian virus 40 infection of humans. J Virol 2003; 77:5039–5045.

    Article  PubMed  CAS  Google Scholar 

  7. Barbanti-Brodano G, Sabbioni S, Martini F et al. Simian Virus 40 infection in humans and association with human diseases: results and hypotheses. Virology 2004; 318:1–8.

    Article  PubMed  CAS  Google Scholar 

  8. Imperiale MJ. The human polyomaviruses, BKV and JCV: molecular pathogenesis of acute disease and potential role in cancer. Virology 2000: 267:1–7.

    Article  PubMed  CAS  Google Scholar 

  9. Imperiale MJ. Oncogenic transformation by the human polyomaviruses. Oncogene 2001; 20:7917–7923.

    Article  PubMed  CAS  Google Scholar 

  10. Imperiale MJ. The human polyomaviruses: an overview. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:53–71.

    Google Scholar 

  11. Moens U, Rekvig OP. Molecular biology of BK virus and clinical and basic aspects of BK virus renal infection. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:359–408.

    Google Scholar 

  12. Yogo Y, Sugimoto C. The archetype concept and regulatory region rearrangement. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: Wiley-Liss, 2001:127–148.

    Google Scholar 

  13. Loeber G, Doerries K. DNA rearrangements in organ-specific variants of polyomavirus JC strain GS. J Virol 1988; 62:1730–1735.

    PubMed  CAS  Google Scholar 

  14. Jorgensen GE, Hammarin AL, Bratt G et al. Identification of a unique BK virus variant in the CNS of a patient with AIDS. J Med Virol 2003; 70:14–19.

    Article  PubMed  CAS  Google Scholar 

  15. Negrini M, Sabbioni S, Arthur RR et al. Prevalence of the archetypal regulatory region and sequence polymorphisms in nonpassaged BK virus variants. J Virol 1991; 65:5092–5095.

    PubMed  CAS  Google Scholar 

  16. Brown P, Tsai T, Gajdusek DC. Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody re valence among remote peoples of the world. Am J Epidemiol 1975; 102:331–340.

    PubMed  CAS  Google Scholar 

  17. Gardner SD. Prevalence in England of antibody to human polyomavirus (BK). BMJ 1973; 1:77–78.

    Google Scholar 

  18. Shah KV, Daniel RW, Warszawski RM. High prevalence of antibodies to BK virus, an SV40-related papovavirus, in residents of Maryland. J Infect Dis 1973; 128:784–787.

    PubMed  CAS  Google Scholar 

  19. Portolani M, Marzocchi A, Barbanti-Brodano G et al. Prevalence in Italy of antibodies to a new human papovavirus (BK virus). J Med Microbiol 1974; 7:543–546.

    Article  PubMed  CAS  Google Scholar 

  20. Padgett BL, Walker DL. Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J Infect Dis 1973; 127:467–470.

    PubMed  CAS  Google Scholar 

  21. Taguchi F, Kajioka J, Miyamura T. Prevalence rate and age of acquisition of antibodies against JC virus and BK virus in human sera. Microbiol Immunol 1982; 26:1057–1062.

    PubMed  CAS  Google Scholar 

  22. Knowles WA, Pipkin P, Andrews N et al. Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 2003; 71:115–123.

    Article  PubMed  Google Scholar 

  23. Stolt A, Sasnauskas K, Koskela P et al. Seroepidemiology of the human polyomaviruses. J Gen Virol 2003; 84:1499–1504.

    Article  PubMed  CAS  Google Scholar 

  24. Carter JJ, Madeleine MM, Wipf GC et al. Lack of serologic evidence for prevalent simian virus 40 infection in humans. J Natl Cancer Inst 2003; 95:1522–1530.

    PubMed  Google Scholar 

  25. Minor P, Pipkin P, Jarzebek Z et al. Studies of neutralising antibodies to SV40 in human sera. J Med Viral 2003; 70:490–495.

    Article  CAS  Google Scholar 

  26. Monini P, De Lellis L, Barbanti-Brodano G. Association of BK and JC human polyomaviruses and SV40 with human tumors. In: Barbanti-Brodano G, Bendinelli M, Friedman H, eds. DNA Tumor Viruses: Oncogenic Mechanisms. New York: Plenum Press, 1995:51–73.

    Google Scholar 

  27. Doerries K. Latent and persistent polyomavirus infection. In: Khalili K, Stoner GL, eds. Human polyomaviruses: molecular and clinical perspectives. New York: Wiley-Liss, 2001:197–235.

    Google Scholar 

  28. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003; 3:611–623.

    Article  PubMed  Google Scholar 

  29. Blake K, Pillay D, Knowles W et al. JC virus associated meningoencephalitis in an immunocompetent girl. Arch Dis Child 1992; 67:956–957.

    Article  PubMed  CAS  Google Scholar 

  30. Shah KV, Nathanson N. Human exposure to SV40. Am J Epidemiol 1976; 103:1–12.

    PubMed  CAS  Google Scholar 

  31. Carbone M, Rizzo P, Pass HI. Simian virus 40, poliovaccines and human tumors: a review of recent developments. Oncogene 1997; 15: 1877–1888.

    Article  PubMed  CAS  Google Scholar 

  32. Melnick JL, Stinebaugh S. Excretion of vacuolating SV40 virus (papova virus group) after ingestion as a contaminant of oral poliovaccine. Proc Soc Ep Biol Med 1962; 109:965–968.

    CAS  Google Scholar 

  33. Ling PD, Lednicky JA, Keitel WA et al. The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study. J Infect Dis 2003; 187:1571–1580.

    Article  PubMed  Google Scholar 

  34. Li RM, Tanawattanacharoen S, Falk RA et al. Molecular identification of SV40 infection in human subjects and possible association with kidney disease. J Am Soc Nephrol 2002; 13:2320–2330.

    Article  PubMed  CAS  Google Scholar 

  35. Li RM, Mannon RB, Kleiner D et al. BK virus and SV40 co-infection in polyomavirus nephropathy. Transplantation 2002; 74: 1497–1504.

    Article  PubMed  Google Scholar 

  36. Sweet BH, Hilleman MR. The vacuolating virus SV40. Proc Soc Exp Biol Med 1960; 105:420–427.

    PubMed  CAS  Google Scholar 

  37. De Mattei M, Martini F, Corallini A et al. High incidence of BK virus large T antigen coding sequences in normal human tissues and tumors of different histotypes. Int J Cancer 1995; 61:756–760.

    Article  PubMed  Google Scholar 

  38. Martini F, Iaccheri L, Carinci P et al. SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals. Cancer Res 1996; 56:4820–4825.

    PubMed  CAS  Google Scholar 

  39. Martini F, Lazzarin L, Iaccheri L et al. Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors. Cancer 2002; 94:1037–1048.

    Article  PubMed  CAS  Google Scholar 

  40. Lecatsas G, Schoub BD, Rabson AR et al. Papovavirus in human lymphocyte cultures. Lancet 1976; 2:907–908.

    Article  PubMed  CAS  Google Scholar 

  41. Schneider EM, Doerries K. High frequency of polyomavirus infection in lymphoid cell preparations after allogenic bone marrow transplantation. Transplant Proc 1993; 25:1271–1273.

    PubMed  CAS  Google Scholar 

  42. Goudsmit J, Wertheim-van Dillen P, van Strien A et al. The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils. J Med Virol 1982; 10:91–99.

    Article  PubMed  CAS  Google Scholar 

  43. Monaco MCG, Jensen PN, Hou J et al. Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol 1998; 72:9918–9923.

    PubMed  CAS  Google Scholar 

  44. Laghi L, Randolph AE, Chauhan DP et al. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U.S.A. 1999; 96:7484–7489.

    Article  PubMed  CAS  Google Scholar 

  45. Ricciardiello L, Laghi L, Ramamirtham P et al. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology 2000; 119:1228–1235.

    Article  PubMed  CAS  Google Scholar 

  46. Ricciardiello L, Chang DK, Laghi L et al. Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. J Virol 2001; 75: 1996–2001.

    Article  PubMed  CAS  Google Scholar 

  47. Bofill-Mas S, Formiga-Cruz M, Clemente-Casares P et al. Potential transmission of human polyomaviruses through the gastrointestinal tract after exposure to virions or viral DNA. J Virol 2001; 75:10290–10299.

    Article  PubMed  CAS  Google Scholar 

  48. Vastag B. Sewage yields clues to SV40 transmission. J Am Med Assoc 2002; 288:1337–1338.

    Article  Google Scholar 

  49. Minor P, Pipkin PA, Cutler K et al. Natural infection and transmission of SV40. Virology 2003; 314:403–409.

    Article  PubMed  CAS  Google Scholar 

  50. Pipas JM, Levine AJ. Role of T antigen interactions with p53 in tumorigenesis. Sem Cancer Biol 2001; 11:23–30.

    Article  CAS  Google Scholar 

  51. Sáenz-Robles MT, Sullivan CS, Pipas JM. Transforming functions of Simian Virus 40. Oncogene 2001; 20:7899–7907.

    Article  PubMed  Google Scholar 

  52. Dyson N, Buchkovich K, Whyte P et al. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 1989; 58:249–255.

    Article  PubMed  CAS  Google Scholar 

  53. Dyson N, Bernards R, Friend SH et al. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol 1990; 64:1353–1356.

    PubMed  CAS  Google Scholar 

  54. Harris KF, Christensen JB, Imperiale MJ. BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control. J Virol 1996; 70:2378–2386.

    PubMed  CAS  Google Scholar 

  55. Shivakumar CV, Das GC. Interaction of human polyomavirus BK with the tumor-suppressor protein p53. Oncogene 1996; 13:323–332.

    PubMed  CAS  Google Scholar 

  56. Sheppard HM, Siska IC, Espiritu C et al. New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen. Mol Cell Biol 1999; 19:2746–2753.

    PubMed  CAS  Google Scholar 

  57. Baysal BE, Farr JE, Goss JR et al. Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. Gene 1998; 217:107–116.

    Article  PubMed  CAS  Google Scholar 

  58. Wang SS, Esplin ED, Li JL et al. Alterations of the PPP2RlB gene in human lung and colon cancer. Science 1998; 282: 284–287.

    Article  PubMed  CAS  Google Scholar 

  59. Calin GA, di Iasio MG, Caprini E et al. Low frequency of alterations of the alpha (PPP2RlA) and beta (PPP2RlB) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene 2000; 19:1191–1195.

    Article  PubMed  CAS  Google Scholar 

  60. Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997; 11:3286–3305.

    Article  PubMed  CAS  Google Scholar 

  61. Willert K, Nusse R. Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 1998; 8:95–102.

    Article  PubMed  CAS  Google Scholar 

  62. Ikeda S, Kishida M, Matsuura Y et al. GSK-3b-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by b-catenin and protein phosphatase 2A complexed with Axin. Oncogene 2000; 19:537–545.

    Article  PubMed  CAS  Google Scholar 

  63. Nunbhakdi-Craig V, Craig L, Machleit T et al. Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells. J Virol 2003; 77:2807–2818.

    Article  PubMed  CAS  Google Scholar 

  64. Gaillard S, Fahrbach KM, Parkati R et al. Overexpression of simian virus 40 small-t antigen blocks centrosome function and mitotic progression in human fibroblasts. J Virol 2001; 75:9799–9807.

    Article  PubMed  CAS  Google Scholar 

  65. Zhao JJ, Gjoerup OV, Subramanian RR et al. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 2003; 3:483–495.

    Article  PubMed  CAS  Google Scholar 

  66. Beck GR Jr, Zerler BR, Moran E. Introduction to DNA tumor viruses: Adenovirus, simian virus 40, and polyomavirus. In: McCance DJ, ed. Human Tumor Viruses. Washington, DC: ASM Press, 1998:51–86.

    Google Scholar 

  67. Loeken MR. Simian virus 40 small t antigen transactivates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1A. J Virol 1992; 66:2551–2555.

    PubMed  CAS  Google Scholar 

  68. Theile M, Grabowski G. Mutagenic activity of BKV and JCV in human and other mammalian cells. Arch Virol 1990; 113:221–233.

    Article  PubMed  CAS  Google Scholar 

  69. Theile M, Strauss M, Luebbe L. SV40-induced somatic mutations: possible relevance to viral transformation. Cold Spring Harbor Symp Quant Biol 1980; 44:377–382.

    PubMed  CAS  Google Scholar 

  70. Ray FA, Peabody DS, Cooper JL et al. SV40 T antigen alone drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts. J Cell Biochem 1990; 42:13–31.

    Article  PubMed  CAS  Google Scholar 

  71. Stewart N, Bacchetti S. Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology 1991; 180:49–57.

    Article  PubMed  CAS  Google Scholar 

  72. Trabanelli C, Corallini A, Gruppioni R et al. Chromosomal aberrations induced by BK virus T antigen in human fibroblasts. Virology 1998; 243:492–496.

    Article  PubMed  CAS  Google Scholar 

  73. Tognon M, Casalone R, Martini F et al. Large T antigen coding sequences of two DNA tumor viruses, BK and SV40 and nonrandom chromosome chances in glioblastoma cell lines. Cancer Genet Cytogenet 1996; 90:17–23.

    Article  PubMed  CAS  Google Scholar 

  74. Lazutka JR, Neel JV, Major EO et al. High titers of antibodies to two human polyomaviruses, JCV and BKV, correlate with increased frequency of chromosomal damage in human lymphocytes. Cancer Lett 1996; 109:177–183.

    Article  PubMed  CAS  Google Scholar 

  75. Neel JV, Major EO, Awa AA et al. Hypothesis: “Rogue cell”-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncogenesis. Proc Natl Acad Sci U.S.A. 1996; 93:2690–2695.

    Article  PubMed  CAS  Google Scholar 

  76. Ricciardiello L, Baglioni M, Giovannini C et al. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res 2003; 63:7256–7262.

    PubMed  CAS  Google Scholar 

  77. Simmons DT, Melendy T, Usher D et al. Simian virus 40 large T antigen binds to topoisomerase I. Virology 1996; 222:365–374.

    Article  PubMed  CAS  Google Scholar 

  78. Dean FB, Bullock P, Murakami Y et al. Simian virus 40 (SV40) DNA replication: SV40 large T antigene unwinds DNA containing the SV40 origin of replication. Proc Natl Acad Sci USA 1987; 84:16–20.

    Article  PubMed  CAS  Google Scholar 

  79. Li D, Zhao R, Lilyestrom W et al. Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature 2003; 423:512–518.

    Article  PubMed  CAS  Google Scholar 

  80. Shein HM, Enders JF. Transformation induced by simian virus 40 in human renal cell cultures. I. Morphology and growth characteristics. Proc Natl Acad Sci U.S.A. 1962; 48:1164–1172.

    Article  PubMed  CAS  Google Scholar 

  81. Koprowski H, Ponten JA, Jensen F et al. Transformation of cultures of human tissue infected with simian virus 40. J Cell Comp Physiol 1962; 59:281–292.

    Article  Google Scholar 

  82. Jensen F, Koprowski H, Pagano JS et al. Autologous and homologous implantation of human cells transformed in vitro by simian virus 40. J Natl Cancer Inst 1964; 32:917–932.

    Google Scholar 

  83. Chen W, Hahn WC. SV40 early region oncoproteins and human cell transformation. Histol Histopathol 2003; 18:541–550.

    PubMed  CAS  Google Scholar 

  84. Purchio AF, Fareed GC. Transformation of human embryonic kidney cells by human papovavirus BK. J Virol 1979; 29:763–769.

    PubMed  CAS  Google Scholar 

  85. Grossi MP, Caputo A, Meneguzzi G et al. Transformation of human embryonic fibroblasts by BK virus, BK virus DNA and a subgenomic BK virus DNA fragment. J Gen Virol 1982; 63:393–403.

    Article  PubMed  CAS  Google Scholar 

  86. Rinaldo CH, Myhre MR, Alstad H et al. Human polyomavirus BK (BKV) transiently transforms and persistently infects cultured osteosarcoma cells. Virus Res 2003; 93:181–187.

    Article  PubMed  CAS  Google Scholar 

  87. Vasavada R, Eager KB, Barbanti-Brodano G et al. Adenovirus type 12 early region 1A proteins repress class I HLA expression in transformed human cells. Proc Natl Acad Sci U.S.A. 1986; 83:5257–5261.

    Article  PubMed  CAS  Google Scholar 

  88. Corallini A, Pagnani M, Viadana P et al. Induction of malignant subcutaneous sarcomas in hamsters by a recombinant DNA containing BK virus early region and the activated human c-Harvey-ras oncogene. Cancer Res 1987; 47:6671–6677.

    PubMed  CAS  Google Scholar 

  89. Corallini A, Pagnani M, Caputo A et al. Cooperation in oncogenesis between BK virus early region gene and the activated human c-Harvey-ras oncogene. J Gen Virol 1988; 69:2671–2679.

    Article  PubMed  CAS  Google Scholar 

  90. Pagnani M, Corallini A, Caputo A et al. Co-operation in cell transformation between BK virus and the human c-Harvey-ras oncogene. Int J Cancer 1988; 42:405–413.

    Article  PubMed  CAS  Google Scholar 

  91. Pater A, Pater MM. Transformation of primary human embryonic kidney cells to anchorage independence by a combinant of BK virus DNA and the Harvey-ras oncogene. J Virol 1986; 58:680–683.

    PubMed  CAS  Google Scholar 

  92. Corallini A, Gianni M, Mantovani C et al. Transformation of human cells by recombinant DNA molecules containing BK virus early region and the human activated c-H-ras or c-myc oncogenes. Cancer Journal 1991; 4:24–34.

    CAS  Google Scholar 

  93. Takemoto KK, Linke H, Miyamura T et al. Persistent BK papovavirus infection of transformed human fetal brain cells. I. Episomal viral DNA in cloned lines deficient in T-antigen expression. J Virol 1979; 29:1177–1185.

    PubMed  CAS  Google Scholar 

  94. Hahn WC, Counter CM, Lundberg AS et al. Creation of human tumour cells with defined genetic elements. Nature 1999; 400:464–468.

    Article  PubMed  CAS  Google Scholar 

  95. London WT, Houff SA, Madden DL et al. Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus). Science 1978; 201:1246–1249.

    Article  PubMed  CAS  Google Scholar 

  96. London WT, Houff SA, MacKeever PE et al. Viral induced astrocytomas in squirrel monkeys. In: Sever JL, Madden DL, eds. Polyomaviruses and Human Neurological Disease. New York: Alan R. Liss, 1983:227–237.

    Google Scholar 

  97. Chen J, Tobin GJ, Pipas JM et al. T antigen mutant activities in vivo: roles pf p53 and pRB binding in tumorigenesis of the choroid plexus. Oncogene 1992; 7:1167–1175.

    PubMed  CAS  Google Scholar 

  98. Van Dyke TA, Finlay C, Miller D et al. Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice. J Virol 1987; 61:2029–2032.

    PubMed  Google Scholar 

  99. Gee GV, Manley K, Atwood WJ. Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism. Virology 2003; 314:101–109.

    Article  PubMed  CAS  Google Scholar 

  100. Corallini A, Altavilla G, Carra’L et al. Oncogenicity of BK virus for immunosuppressed hamsters. Arch Virol 1982; 73:243–253.

    Article  PubMed  CAS  Google Scholar 

  101. Walker DL, Padgett BL, zu Rhein GM, et al. Human papovavirus (JC): Induction of brain tumors in hamsters. Science 1973; 181:674–676.

    Article  PubMed  CAS  Google Scholar 

  102. Del Valle L, Gordon J, Ferrante P et al. JC virus in experimental and clinical brain tumorigenesis. In: Khalili K, Stoner GL, eds. Human polyomaviruses: molecular and clinical perspectives. New York: Wiley-Liss, 2001:409–430.

    Google Scholar 

  103. Varakis JN, zu Rhein GM, Padgett BL et al. Experimental (JC virus-induced) neuroblastomas in the Syrian hamster. J Neuropathol Exp Neurol 1976; 35:314.

    Article  Google Scholar 

  104. Ohashi T, zu Rhein GM, Varakis J et al. Experimental (JC virus-induced) intraocular and extraorbital tumors in the Syrian hamster. J Neuropathol Exp Neurol 1978; 37:667.

    Article  Google Scholar 

  105. Padgett BL, Walker DL, zu Rhein GM et al. Differential neuro-oncogenicity of strains of JC virus, a human polyomavirus, in newborn Syrian hamsters. Cancer Res 1977; 37:718–725.

    PubMed  CAS  Google Scholar 

  106. Miller NR, McKeever PE, London WT et al. Brain tumors of owl monkeys inoculated with JC virus contain the JC virus genome. J Virol 1984; 49:848–856.

    PubMed  CAS  Google Scholar 

  107. Major EO, Mourrain P, Cummins C. JC virus-induced owl monkey glioblastoma cells in culture: biological properties associated with the viral early gene product. Virology 1984; 136:359–367.

    Article  PubMed  CAS  Google Scholar 

  108. Cicala C, Pompetti F, Carbone M. SV40-induced mesotheliomas in hamsters. Am J Pathol 1993; 142:1524–1533.

    PubMed  CAS  Google Scholar 

  109. Small JA, Khoury G, Jay G et al. Early regions of JC virus and BK virus induce distinct and tissue specific tumors in transgenic mice. Proc Natl Acad Sci U.S.A. 1986; 83:8288–8292.

    Article  PubMed  CAS  Google Scholar 

  110. Dalrymple SA, Beemon KL. BK virus T antigens induce kidney carcinomas and thymoproliferative disorders in transgenic mice: J Virol 1990; 64:1182–1191.

    PubMed  CAS  Google Scholar 

  111. Brinster RL, Chen HY, Messing A et al. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 1984; 37:367–379.

    Article  PubMed  CAS  Google Scholar 

  112. Palmiter R, Chen H, Messing A et al. SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice. Nature 1985; 316:457–460.

    Article  PubMed  CAS  Google Scholar 

  113. Feigenbaum L, Hinrichs SH, Jay G. JC virus and simian virus 40 enhancers and transforming proteins: role in determining tissue specificity and pathogenicity in transgenic mice. J Virol 1992; 66:1176–1182.

    PubMed  CAS  Google Scholar 

  114. Fiori M, Di Mayorca G. Occurrence of BK virus DNA in DNA obtained from certain human tumors. Proc Natl Acad Sci USA 1976; 73:4662–4666.

    Article  PubMed  CAS  Google Scholar 

  115. Pater MM, Pater A, Fiori M et al. BK virus DNA sequences in human tumors and normal tissues and cell lines. In: Essex M, Todaro G, zur Hausen H, eds. Viruses in Naturally Occurring Cancers. Book A. Cold Spring Harbor Conferences on Cell Proliferation. New York: Cold Spring Harbor Laboratory Press, 1980:329–341.

    Google Scholar 

  116. Corallini A, Pagnani M, Viadana P et al. Association of BK virus with human brain tumors and tumors of pancreatic islets. Int J Cancer 1987; 39:60–67.

    Article  PubMed  CAS  Google Scholar 

  117. Caputo A, Corallini A, Grossi MP et al. Episomal DNA of a BK virus variant in a human insulinoma. J Med Virol 1983; 12:37–49.

    Article  PubMed  CAS  Google Scholar 

  118. Pagnani M, Negrini M, Reschinglian P et al. Molecular and biological properties of BK virus-IR, a BK virus variant rescued from a human tumor. J Virol 1986; 59:500–505.

    PubMed  CAS  Google Scholar 

  119. Calos MP, Miller JH. Tansposable elements. Cell 1980; 20:579–595.

    Article  PubMed  CAS  Google Scholar 

  120. Doerries K, Loeber G, Meixenberger J. Association of polyomavirus JC, SV40 and BK with human brain tumors. Virology 1987; 160:268–270.

    Article  Google Scholar 

  121. Flaegstad T, Andresen PA, Johnsen JI et al. A possible contributory role of BK virus infection in neuroblastoma development. Cancer Res 1999; 59:1160–1163.

    PubMed  CAS  Google Scholar 

  122. Knoll A, Stoehr R, Jilg W et al. Low frequency of human polyomavirus BKV and JCV DNA in urothelial carcinomas of the renal pelvis and renal cell carcinomas. Oncol Rep 2003; 10:487–491.

    PubMed  Google Scholar 

  123. Monini P, Rotola A, Di Luca D et al. DNA rearrangements impairing BK virus productive infection in urinary tract tumors. Virology 1995; 214:273–279.

    Article  PubMed  CAS  Google Scholar 

  124. Geetha D, Tong BC, Racusen L et al. Bladder carcinoma in a transplant recipient: evidence to implicate the BK human polyomavirus as a causal transforming agent. Transplantation 2002; 73:1933–1936.

    Article  PubMed  Google Scholar 

  125. Zambrano A, Kalantari M, Simoneau A et al. Detection of human polyomaviruses and papillomaviruses in prostatic tissue reveals the prostate as a habitat for multiple viral infections. Prostate 2002; 53:263–276.

    Article  PubMed  CAS  Google Scholar 

  126. Negrini M, Rimessi P, Mantovani C et al. Characterization of BK virus variants rescued from human tumours and tumour cell lines. J Gen Virol 1990; 71:2731–2736.

    Article  PubMed  CAS  Google Scholar 

  127. Monini P, Rotola A, De Lellis L et al. Latent BK virus infection and Kaposi’s sarcoma pathogenesis. Int J Cancer 1996; 66:717–722.

    Article  PubMed  CAS  Google Scholar 

  128. Peterman TA, Jaffe HW, Beral V. Epidemiologic clues to the etiology of Kaposi’s sarcoma. AIDS 1993; 7:605–611.

    Article  PubMed  CAS  Google Scholar 

  129. Williams RL, Risau W, Zerwes HG et al. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 1989; 57:1053–1063.

    Article  PubMed  CAS  Google Scholar 

  130. O’Connel K, Landman G, Farmer E et al. Endothelial cells transformed by SV40 T antigen cause Kaposi’s sarcoma like tumors in nude mice. Am J Pathol 1991; 139:743–749.

    Google Scholar 

  131. Corallini A, Possati L, Trabanelli C et al. Tumor-host interaction mediates the regression of BK virus-induced vascular tumors in mice: involvement of transforming growth factor-beta 1. Carcinogenesis 2003; 24:1435–1444.

    Article  PubMed  CAS  Google Scholar 

  132. Arthur RR, Grossman SA, Ronnett BM et al. Lack of association of human polyomaviruses with human brain tumors. J Neuro-Oncol 1994; 20:55–58.

    Article  CAS  Google Scholar 

  133. Volter C, zur Hausen H, Alber D et al. Screening human tumor samples with a broad-spectrum polymerase chain reaction method for the detection of polyomaviruses. Virology 1997; 237:389–396.

    Article  PubMed  CAS  Google Scholar 

  134. MacKenzie J, Perry J, Ford AM et al. JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukemia. Brit J Cancer 1999; 81:898–899.

    Article  PubMed  CAS  Google Scholar 

  135. Kim JY, Koralnik IJ, LeFave M et al. Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences. Neuro-oncology 2002; 4:165–170.

    Article  PubMed  CAS  Google Scholar 

  136. Rencic A, Gordon J, Otte J et al. Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. Proc Natl Acad Sci USA 1996; 93:7352–7357.

    Article  PubMed  CAS  Google Scholar 

  137. Caldarelli-Stefano R, Boldorini R, Monga G et al. JC virus in human glial-derived tumors. Hum Pathol 2000; 31:394–395.

    Article  PubMed  CAS  Google Scholar 

  138. Del Valle L, Gordon J, Enam S et al. Expression of human neutropic polyomavirus JCV late gene product agnoprotein in human medulloblastoma. J Natl Cancer Inst 2002; 94:267–273.

    PubMed  Google Scholar 

  139. Boldorini R, Caldarelli-Stefano R, Monga G et al. PCR detection of JC virus DNA in the brain tissue of a 9-year-old child with pleomorphic xanthoastrocytoma. J Neurovirol 1998; 4:242–245.

    Article  PubMed  CAS  Google Scholar 

  140. Krynska B, Del Valle L, Croul S et al. Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas. Proc Natl Acad Sci USA 1999; 96:11519–11524.

    Article  PubMed  CAS  Google Scholar 

  141. Krynska B, Otte J, Franks R et al. Human ubiquitous JCV(CY) T-antigen gene induces brain tumors in experimental animals. Oncogene 1999; 18:39–46.

    Article  PubMed  CAS  Google Scholar 

  142. Del Valle L, Gordon J, Assimakopoulou M et al. Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system. Cancer Res 2001; 61:4287–4293.

    PubMed  Google Scholar 

  143. Del Valle L, Delbue S, Gordon J et al. Expression of JC virus T-antigen in a patient with MS and glioblastoma multiforme. Neurology 2002; 58:895–900.

    PubMed  Google Scholar 

  144. Del Valle L, Enam S, Lara C et al. Detection of JC polyomavirus DNA sequences and cellular localization of T-antigen and agnoprotein in oligodendrogliomas. Clin Cancer Res 2002; 8:3332–3340.

    PubMed  Google Scholar 

  145. Boldorini R, Pagani E, Car PG et al. Molecular characterisation of JC virus strains detected in human brain tumours. Pathology 2003; 35:248–253.

    Article  PubMed  CAS  Google Scholar 

  146. Safak M, Barrucco R, Darbinyan A et al. Interaction of JC virus agnoprotein with T antigen modulates transcription and replication of the viral genome in glial cells. J Virol 2001; 75:1476–1486.

    Article  PubMed  CAS  Google Scholar 

  147. Endo S, Okada Y, Orba Y et al. JC virus agnoprotein colocalizes with tubulin. J Neurovirol 2003; 9Suppl 1:10–14.

    Article  PubMed  CAS  Google Scholar 

  148. Enam S, Del Valle L, Lara C et al. Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and beta-catenin. Cancer Res 2002; 62:7093–7101.

    PubMed  CAS  Google Scholar 

  149. Gan DD, Reiss K, Gorrill T et al. Involvement of Wnt signaling pathway in murine medulloblastoma induced by human neurotropic JC virus. Oncogene 2001; 20:4864–4870.

    Article  PubMed  CAS  Google Scholar 

  150. Galdenzi G, Lupo A, Anglani F et al. Is the simian virus SV 40 associated with idiopathic focal segmental glomerulosclerosis in humans? J Nephrol 2003; 16:350–356.

    PubMed  CAS  Google Scholar 

  151. Arrington AS, Butel JS. SV40 and human tumors. In: Khalili K, Stoner GL, eds. Human Polyomaviruses: molecular and clinical perspectives. New York: Wiley-Liss, 2001:461–489.

    Google Scholar 

  152. Gazdar AF, Butel JS, Carbone M. SV 40 and human tumours: myth, association or causality? Nature Rev Cancer 2002; 2:957–964.

    Article  CAS  Google Scholar 

  153. Vilchez RA, Butel JS. SV40 in human brain cancers and non-Hodgkin’s lymphoma. Oncogene 2003; 22:5164–5172.

    Article  PubMed  CAS  Google Scholar 

  154. Mendoza SM, Konishi T, Miller CW. Integration of SV40 in human osteosarcoma DNA. Oncogene 1998; 17:2457–2462.

    Article  PubMed  CAS  Google Scholar 

  155. Pacini F, Vivaldi A, Santoro M et al. Simian virus 40-like DNA sequences in human papillary thyroid carcinomas. Oncogene 1998; 16:665–669.

    Article  PubMed  CAS  Google Scholar 

  156. Lednicky JA, Garcea RL, Bergsagel DJ et al. Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Virology 1995; 212:710–717.

    Article  PubMed  CAS  Google Scholar 

  157. Capello D, Rossi D, Gaudino G et al. Simian virus 40 infection in lymphoproliferative disorders. Lancet 2003; 361:88–89.

    Article  PubMed  Google Scholar 

  158. De Sanjose S, Shah KV, Domingo-Domenench E et al. Lack of serological evidence for an association between simian virus 40 and lymphoma. Int J Cancer 2003; 104:522–524.

    Article  PubMed  CAS  Google Scholar 

  159. Engels EA, Sarkar C, Daniel RW et al. Absence of simian virus 40 in human brain tumors from Northern India. Int J Cancer 2002; 101:348–352.

    Article  PubMed  CAS  Google Scholar 

  160. Gordon GJ, Chen CJ, Jaklitsch MT et al. Detection and quantification of SV40 large T-antigen DNA in mesothelioma tissues and cell lines. Oncol Rep 2002; 9:631–634.

    PubMed  CAS  Google Scholar 

  161. MacKenzie J, Wilson KS, Perry J et al. Association between simian virus 40 DNA and lymphoma in the United Kingdom. J Natl Cancer Inst 2003; 95:1001–1003.

    Article  PubMed  CAS  Google Scholar 

  162. Mayall F, Barratt K, Shanks J. The detection of simian virus 40 in mesotheliomas from New Zeland and England using real time FRET probe PCR protocols. J Clin Pathol 2003; 56:728–730.

    Article  PubMed  CAS  Google Scholar 

  163. Shah KV. Does SV40 infection contribute to the development of human cancers? Rev Med Virol 2000; 10:31–43.

    Article  PubMed  CAS  Google Scholar 

  164. Strickler HD and The International SV40 Working Group. A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens. Cancer Epidemiol Biomark Prev 2001; 10:523–532.

    CAS  Google Scholar 

  165. Carbone M, Bocchetta M, Cristaudo A et al. SV40 and human brain tumors. Int J Cancer 2003; 106:140–142.

    Article  PubMed  CAS  Google Scholar 

  166. Engels EA, Gravitt PE, Daniel RW et al. Absence of simian virus 40 in human brain tumors from Northern India; response to letter from Carbone et al. Int J Cancer 2003; 106:143–145.

    Article  CAS  Google Scholar 

  167. Rollison DEM, Helzlsouer KJ, Alberg AJ et al. Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors. Cancer Epidemiol Biomark Prev 2003; 12:460–463.

    Google Scholar 

  168. Engels EA, Rodman LH, Frisch M et al. Childhood exposure to simian virus 40-contaminated poliovirus vaccine and risk of AIDS-associated non-Hodgkin’s lymphoma. Int J Cancer 2003; 106:283–287.

    Article  PubMed  CAS  Google Scholar 

  169. zur Hausen H. SV 40 in humans cancers: an endless tale? Int J Cancer 2003; 107:687.

    Article  PubMed  CAS  Google Scholar 

  170. Testa JR, Carbone M, Hirvonen A et al. A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas. Cancer Res 1998; 58:4505–4509.

    PubMed  CAS  Google Scholar 

  171. Vilchez RA, Butel JS. Simian virus 40 and its association with human lymphomas. Curr Oncol Rep 2003; 5:372–379.

    Article  PubMed  Google Scholar 

  172. Vilchez RA, Kozinetz CA, Arrington AS et al. Simian virus 40 in human cancers. Am J Med 2003; 114:675–684.

    Article  PubMed  Google Scholar 

  173. Brugge JS, Butel, JS. Role of simian virus 40 gene A function in maintenance of transformation. J Virol 1975; 15:619–635.

    PubMed  CAS  Google Scholar 

  174. Martin RG, Chou JY. Simian virus 40 functions required for the establishment and maintenance of malignant transformation. J Virol 1975; 15:599–612.

    PubMed  CAS  Google Scholar 

  175. Osborn M, Weber K. Simian virus 40 gene A function and maintenance of transformation. J Virol 1975; 15:636–644.

    PubMed  CAS  Google Scholar 

  176. Tegtmeyer P. Function of simian virus 40 gene A in transforming infection. J Virol 1975; 15:613–618.

    PubMed  CAS  Google Scholar 

  177. Coleman WB, Tsongalis GJ. The role of genomic instability in the development of human cancer. In: Coleman WB, Tsongalis GJ, eds. The Molecular Basis of Human Cancer. Totowa: Humana Press, 2002:115–142.

    Google Scholar 

  178. Reinartz JJ. Cancer genes. In: Coleman WB, Tsongalis GJ, eds. The Molecular Basis of Human Cancer. Totowa, NJ: Humana Press, 2002:45–64.

    Google Scholar 

  179. Shimamoto T, Ohyashiki K. Chromosomes and chromosomal instability in human cancer. In: Coleman WB, Tsongalis GJ, eds. The Molecular Basis of Human Cancer. Totowa: Humana Press, 2002:143–158.

    Google Scholar 

  180. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643–649.

    Article  PubMed  CAS  Google Scholar 

  181. Galloway DA, McDougall JK. The oncogenic potential of herpes simplex viruses: evidence for a ‘hit and run’ mechanism. Nature 1983; 302:21–24.

    Article  PubMed  CAS  Google Scholar 

  182. Schlehofer JR, zur Hausen H. Induction of mutations within the host cell genome by partially inactivated herpes simplex virus type 1. Virology 1982; 122:471–475.

    Article  PubMed  CAS  Google Scholar 

  183. Porcu P, Ferber A, Pietrzkowski Z et al. The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulin-like growth factor 1 with its receptor. Mol Cell Biol 1992; 12:5069–5077.

    PubMed  CAS  Google Scholar 

  184. Cacciotti P, Libener R, Betta P et al. SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma. Proc Natl Acad Sci USA 2001; 98:12032–12037.

    Article  PubMed  CAS  Google Scholar 

  185. Cacciotti P, Strizzi L, Vianale G et al. The presence of simian virus 40 sequences in mesothelioma and mesothelial cells is associated with high levels of vascular endothelial growth factor. Am J Respir Cell Mol Biol 2002; 26:189–193.

    PubMed  CAS  Google Scholar 

  186. Catalano A, Romano M, Martinotti S et al. Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen. Oncogene 2002; 21:2896–2900.

    Article  PubMed  CAS  Google Scholar 

  187. Carbone M, Pass HI, Miele L et al. New developments about the association of SV40 with human mesothelioma. Oncogene 2003; 22:5173–5180.

    Article  PubMed  CAS  Google Scholar 

  188. Carbone M, Rizzo P, Grimley PM et al. Simian virus-40 large T-antigen binds p53 in human mesotheliomas. Nature Med 1997; 3:908–912.

    Article  PubMed  CAS  Google Scholar 

  189. De Luca A, Baldi A, Esposito V et al. The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas. Nature Med 1997; 3:913–916.

    Article  PubMed  Google Scholar 

  190. Bocchetta M, Miele L, Pass HI et al. Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells. Oncogene 2003; 22:81–89.

    Article  PubMed  CAS  Google Scholar 

  191. Waheed I, Guo ZS, Chen GA et al. Antisense to SV40 early gene region induces growth arrest and apoptosis in T-antigen-positive human pleural mesothelioma cells. Cancer Res 1999; 59:6068–6073.

    PubMed  CAS  Google Scholar 

  192. Bright RK, Kimchl ET, Shearer MH et al. SV40 Tag-specific cytotoxic T lymphocytes generated from the pheripheral blood of malignant pleural mesothelioma patients. Cancer Immunol Immunother 2002; 50:682–690.

    Article  PubMed  CAS  Google Scholar 

  193. Procopio A, Strizzi L, Vianale G et al. Simian virus-40 sequences are a negative prognostic cofactor in patients with malignant pleural mesothelioma. Genes Chrom Cancer 2000; 29:173–179.

    Article  PubMed  CAS  Google Scholar 

  194. Bocchetta M, Di Resta I, Powers A et al. Human mesothelial cells are unusually susceptible to SV40-mediated transformation and asbestos co-carcinogenicity. Proc Natl Acad Sci U S A 2000; 97:10214–10219.

    Article  PubMed  CAS  Google Scholar 

  195. Carbone M, Burck C, Rdzanek M et al. Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation. Cancer Res 2003; 63:6125–6129.

    PubMed  CAS  Google Scholar 

  196. Dubes GR. Asbestos mediates viral DNA transformation of mouse cells to produce multilayered foci. Proc Am Assoc Cancer Res 1993; 34:185.

    Google Scholar 

  197. Cristaudo A, Foddis R, Bigdeli L et al. SV 40: a possible co-carcinogen of asbestos in the pathogenesis of mesothelioma? Med Lav 2002; 93:499–506.

    PubMed  CAS  Google Scholar 

  198. Dopp E, Poser I, Papp T. Interphase FISH analysis of cell cycle genes in asbestos-treated human mesothelial cells (HMC), SV40-transformed HMC (MET-5A) and mesothelioma cells (COLO). Cell Mol Biol 2002; 48:271–277.

    Google Scholar 

  199. Foddis R, De Rienzo A, Broccoli D et al. SV40 infection induces telomerase activity in human mesothelial cells. Oncogene 2002; 21:1434–1442.

    Article  PubMed  CAS  Google Scholar 

  200. Stratton K, Almario DA, McCormick MC. SV40 contamination of polio vaccine and cancer. Immunization Safety Review Committee, Board of Health Promotion and Disease Prevention, Institute of Medicine of the National Academies. Washington DC: National Academies Press, 2002 (www.nap.edu)

    Google Scholar 

  201. Vilchez RA, Kozinetz A, Butel JS. Conventional epidemiology and the link between SV40 and human cancers. Lancet Oncol 2003; 4:188–191.

    Article  PubMed  CAS  Google Scholar 

  202. Imperiale MJ, Pass HI, Sanda MG. Prospects for an SV40 vaccine. Semin Cancer Biol 2001; 11:81–85.

    Article  PubMed  CAS  Google Scholar 

  203. Xie YC, Hwang C, Overwijk W et al. Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen. J Natl Cancer Inst 1999; 91:169–175.

    Article  PubMed  CAS  Google Scholar 

  204. Kennedy RC, Shearer MH, Watts AM et al. CD4+ T lymphocytes play a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen. Cancer Res 2003; 63:1040–1045.

    PubMed  CAS  Google Scholar 

  205. Cho KB, Chong KY. Absence of mutation in the p53 and the retinoblastoma susceptibility genes in primary cervical carcinomas. Virology 1993; 193:1042–1046.

    Article  Google Scholar 

  206. Lee YY, Wilcznyski SP, Chumakov A et al. Carcinoma of the vulva: HPV and p53 mutations. Oncogene 1994; 9:1655–1659.

    PubMed  CAS  Google Scholar 

  207. Goedert JJ, ed. Infectious causes of cancer. Totowa: Humana Press, 2000.

    Google Scholar 

  208. Newton R, Beral V, Weiss RA, eds. Infections and human cancer. Cancer Surveys vol 33. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1999.

    Google Scholar 

  209. McNally RJQ, Cairns DP, Eden OB et al. An infectious aetiology for childhood brain tumours? Evidence from space—Time clustering and seasonality analyses. British J Cancer 2002; 86:1070–1077.

    Article  CAS  Google Scholar 

  210. Larsen LS. Brain tumors incidence rising; researchers ask why. J Natl Cancer Inst 1993; 85:1024–1025.

    Article  PubMed  CAS  Google Scholar 

  211. Mortimer EA Jr, Lepow ML, Gold E et al. Long-term follow-up of persons inadvertently inoculated with SV40 as neonates. N Engl J Med 1981; 305:1517–1518.

    PubMed  Google Scholar 

  212. Geissler E. SV40 and human tumors. Prog Med Virol 1990; 37:211–222.

    PubMed  CAS  Google Scholar 

  213. Carroll-Pankhurst C, Engels EA, Strickler HD et al. Thirty-five year mortality following receipt of SV40-contaminated polio vaccine during the neonatal period. Brit J Cancer 2001; 85:1295–1297.

    Article  PubMed  CAS  Google Scholar 

  214. zur Hausen H. Viruses in human cancers. Science 1991; 254:1167–1173.

    Article  PubMed  Google Scholar 

  215. zur Hausen H. Viral oncogenesis. In: Parsonnet J, ed. Microbes and Malignancy. New York: Oxford Press, 1999:107–130.

    Google Scholar 

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Authors and Affiliations

  1. University of Ferrara, Ferrara, Italy

    Giuseppe Barbanti-Brodano M.D., Silvia Sabbioni Ph.D., Fernanda Martini Ph.D., Massimo Negrini Ph.D., Alfredo Corallini Ph.D. & Mauro Tognon Ph.D.

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  1. Giuseppe Barbanti-Brodano M.D.
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  1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, Florida, USA

    Nasimul Ahsan M.D., FACP

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Barbanti-Brodano, G., Sabbioni, S., Martini, F., Negrini, M., Corallini, A., Tognon, M. (2006). BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_23

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