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Mesenchymal Stem Cells - Basics and Clinical Application II pp 19–37Cite as

Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 130))

Abstract

Mesenchymal stromal cells (MSCs) have initially been characterized as a fibroblastlike cell population that can be expanded readily in vitro, and is able to support hematopoiesis in vitro and in vivo. By serendipity it was discovered that MSCs can also be administered into the bloodstream. This mode of application formed a major breakthrough in the clinical use of MSCs, because MSC transplantation was found to cure severe immune hyperactivation states such as graft-versus-host disease after allogeneic bone marrow transplantation, or bacterial sepsis. However, MSCs were found difficult to trace and consensus to date is lacking in the scientific community as to where transplanted MSCs end up in the body and which major principles are responsible for the therapeutic effects of MSCs. This chapter gives an overview of the current knowledge on interactions of freshly transplanted MSCs with the cells in the blood stream and the vessel wall, with major organs such as lung, liver, gut, and spleen, and discusses the limitations of the methodologies used to trace transplanted MSCs. The findings will be put into perspective on how therapeutically applied, culture-expanded MSCs may exert beneficial effects.

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  1. Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig Maximilians University München, Marchioninistrasse 15, 81433, Munich, Germany

    Beate Wagner & Reinhard Henschler

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  1. Beate Wagner
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  2. Reinhard Henschler
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Correspondence to Reinhard Henschler .

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Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy

    Massimo Dominici

  3. Medizinische Hochschule Hannover, AG Biochemie und Tumorbiologie, Klinik für Frauenheilkunde und Geburtshilfe, Hannover, Germany

    Ralf Hass

  4. Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Wien, Austria

    Cornelia Kasper

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Wagner, B., Henschler, R. (2012). Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application II. Advances in Biochemical Engineering/Biotechnology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_155

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