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Gastroesophageal Reflux Disease pp 81–92Cite as

EGJ Dysfunction and GERD

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Conclusion

Theories of the mechanism of gastroesophageal junction competence have seesawed between strictly anatomic explanations, focusing on type-I hiatus hernia, and physiologic explanations focusing on the vigor of LES contraction while ignoring the significance of anatomic factors. As detailed above, current thinking recognizes contributions from both sphincteric components. Furthermore, there is an increasing understanding of mechanical elements of the antireflux barrier, inclusive of, but nor restricted to hiatus hernia and the intrinsic LES. Thus, our view of GERD pathogenesis as it pertains to EGJ competence is now focusing on quantifying the mechanical properties of this complex anatomical zone. Future research will likely focus on methods to measure EGJ compliance and elasticity, as these are the mechanical parameters that influence gastroesophageal reflux.

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Authors and Affiliations

  1. Department of Medicine, Northwestern University’s Feinberg School of Medical School, Chicago, IL, USA

    P. J. Kahrilas & J. E. Pandolfino

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  1. P. J. Kahrilas
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  2. J. E. Pandolfino
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Editors and Affiliations

  1. Allgemein öffentliches Krankenhaus, Zell am See, Austria

    Frank A. Granderath , Thomas Kamolz  & Rudolph Pointner ,  & 

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Kahrilas, P.J., Pandolfino, J.E. (2006). EGJ Dysfunction and GERD. In: Granderath, F.A., Kamolz, T., Pointner, R. (eds) Gastroesophageal Reflux Disease. Springer, Vienna. https://doi.org/10.1007/3-211-32317-1_7

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  • DOI: https://doi.org/10.1007/3-211-32317-1_7

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-23589-8

  • Online ISBN: 978-3-211-32317-5

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