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Intracranial Pressure and Brain Monitoring XII pp 373–376Cite as

Increased intracranial pressure induces a rapid systemic interleukin-10 release through activation of the sympathetic nervous system

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Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 95))

Summary

There is a bi-directional communication between the immune and central nervous system. In this context, it is known that patients with traumatic brain injury suffered from systemic immunodepression and an increased risk to develop infectious complications. We investigated the role of an increased intracranial pressure (ICP) and sympathetic activation on systemic immune changes. A sustained increase in ICP was achieved by inflation of a subdural balloon. At different time points, plasma levels of the anti-inflammatory cytokine, interleukin (IL)-10, were measured. Furthermore, the effect of a sympathetic blockade by co-administration of the β2-adreoreceptor antagonist, propranolol, was evaluated. Finally, we examined the impact of epinephrine infusion on blood IL-10 levels. We showed that an increase in ICP with activation of the sympathetic nervous system was able to induce systemic release of IL-10. This effect was blocked by administration of the β2-adreoreceptor antagonist. Furthermore, epinephrine infusion directly induced systemic release of IL-10. Our data suggested that sympathetic activation with release of epinephrine may induce systemic immunodepression with risk of infectious complications in brain-injured patients.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Charité Campus Virchow-Klinkum, Berlin, Germany

    PD Dr. med. C. Woiciechowsky

  2. Department of Medical Immunology, Charité Campus Mitte, University Medicine of Berlin, Berlin, Germany

    H. -D. Volk

Authors
  1. PD Dr. med. C. Woiciechowsky
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  2. H. -D. Volk
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Corresponding author

Correspondence to C. Woiciechowsky .

Editor information

Editors and Affiliations

  1. Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

    Wai S. Poon , Matthew T. V. Chan , Keith Y. C. Goh , Joseph M. K. Lam  & Stephanie C. P. Ng , , ,  & 

  2. Medical College of Virginia Commonwealth University, Virginia, USA

    Anthony Marmarou

  3. Academisch Ziekenhuis Dijkzigt, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Cees J. J. Avezaat

  4. Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK

    John D. Pickard , Marek Czosnyka  & Peter J. A. Hutchinson ,  & 

  5. School of Medicine, Nihon University, Tokyo, Japan

    Yoichi Katayama

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© 2005 Springer-Verlag

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Woiciechowsky, C., Volk, H.D. (2005). Increased intracranial pressure induces a rapid systemic interleukin-10 release through activation of the sympathetic nervous system. In: Poon, W.S., et al. Intracranial Pressure and Brain Monitoring XII. Acta Neurochirurgica Supplementum, vol 95. Springer, Vienna. https://doi.org/10.1007/3-211-32318-X_76

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  • DOI: https://doi.org/10.1007/3-211-32318-X_76

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-24336-7

  • Online ISBN: 978-3-211-32318-2

  • eBook Packages: MedicineMedicine (R0)

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