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Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003;304:437–444.(This is a concise review on the mechanisms of mitochondrial membrane permeabilization and release of cytochrome c. The authors indicate a coordinated onset of the mitochondrial outer membrane breakage and inner membrane disruption leading to complete release of cytochrome c and mitochondrial dysfunction that is typical of many apoptotic deaths.)
Guicciardi ME, Gores GJ. AIP1: a new player in TNF signaling. J Clin Invest 2003;111:1813–1835. (This comment summarizes the uncovering of new players that mediate TNF apoptosis, providing an example of the expanding family of intermediates that contribute to TNF-induced cell death. This new protein, AIP-1, associates with ASK1 and keeps it inactive. In response to TNF, AIP1 dissociates from ASK1, which then activates JNK and p38 MAPK signaling cascades leading to cell death.)
Cauwels A, Janssen B, Waeytens A et al. Caspase inhibition causes hyperacute TNF-induced shock via oxidative stress and phospholipase A2. Nat Immunol 2003;4:387–393. (This is an interesting study providing evidence for a non-traditional role of caspases. Rather than leading to protection, caspase inhibition resulted in susceptibility to TNF and demonstrated the pathophysiological relevance of caspase-independent, ROS-mediated pathways in response to lethal TNF-induced shock in mice.)
Allende ML, Proia RL. Lubricating cell signaling pathways with gangliosides. Curr Opin Struc Biol 2002;12:587–592.
Birbes H, Bawab SE, Hannun YA, Obeid LM. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J 2001;14:2669–2679.
Brenner C, Kroemer G. Apoptosis. Mitochondria — the death signal integrators. Science 2000;289:1150–1151.
Canbay A, Guicciardi ME, Miyoshi H et al. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest 2003;112:152–159.
Chang NS, Pratt N, Heath J et al. Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem 2001;276:3361–3370.
Colel A, Garcia-Ruiz C, Miranda M et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998;115:1541–1551.
Colell A, Garcia-Ruiz C, Roman J et al. Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappaB-dependent survival pathway. FASEB J 2001;15:1068–1070.
Colell A, Morales A, Fernandez-Checa JC, Garcia-Ruiz C. Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-mediated apoptosis in HT-29 cells through glycosphingolipid generation. Possible role of ganglioside GD3. FEBS Lett 2002;526:135–141.
Coll O, Colell A, Garcia-Ruiz C et al. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology 2003;38:692–702.
Copani A, Melchiorri D, Caricasole A et al. Beta-amyloid-induced synthesis of ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons. J Neurosci 2002;22:3963–3968.
Cremesti AE, Goñi FM, Kolesnick RN. Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? FEBS Lett 2002;531:47–53.
Deng Y, Ren X, Li Y et al. A JNK-dependent pathway is required for TNF-induced apoptosis. Cell 2003;115:61–70.
DeMaria R, Lenti T, Malissan F et al. Requirement for GD3 ganglioside in ceramide-induced apoptosis. Science 1997;277:1652–1655.
Du C, Fang M, Li Y et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102:33–42.
Faubion WA, Gores GJ. Death receptors in liver biology and pathobiology. Hepatology 1999;29:1–4.
Feldstein AE, Canbay A, Angulo P et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125:437–443.
Fernandez-Checa JC. Redox regulation and signaling lipids in mitochondrial apoptosis. Biochem Biophys Res Commun 2003;304:471–479.
Fernandez-Checa JC, Colell A, Garcia-Ruiz C. S-adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease. Alcohol 2002;27:179–183.
Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C et al. Glutathione transport in mitochondria: defense against TNF-induced oxidative stress and alcohol. Am J Physiol 1997;273:G7–G17.
Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nature Cell Biol 2001;3:E255–E263.
Galle PR, Krammer PH. CD95-induced apoptosis in human liver disease. Sem Liver Dis 1998;18:141–151.
Garcia-Ruiz C, Colell A, Mari M et al. Defective TNF-a-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 2003;111:197–203.
Garcia-Ruiz C, Colell A, Morales A et al. Trafficking of GD3 to mitochondria by tumor necrosis factor-α. J Biol Chem 2002;277:36443–36448.
Garcia-Ruiz C, Mari M, Morales A et al. Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes. Hepatology 2000;32:56–65.
García-Ruiz C, Colell A, París R, Fernández-Checa JC. Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release and caspase activation. FASEB J 2000;14:847–858.
Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309–1312.
Guicciardi ME, Deussing J, Miyoshi H et al. Cathepsin B contributes to TNF-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 2000;106:1127–1137.
Hall E, Ren S, Hylemon P et al. Detection of a StaR-like mitochondrial cholesterol transporter in HepG2 cells. Hepatology 2002;36:298A.
Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol 2000;10:73–80.
Hedge R, Srinivasula SM, Zhang Z et al. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP-caspase interaction. J Biol Chem 2002;277:432–438.
Jacotot E, Kerri K, El Hamel C et al. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. J Exp Med 2001;193:509–519.
Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 2003;304:463–470.
Kolesnick RN, Kronke M. Regulation of ceramide production and apoptosis. Annu Rev Physiol 1998;60:643–665.
Kuwana T, Mackey MR, Perkins G et al. Bid, Bax and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002;111:331–342.
Li LY, Luo X, Wang X et al. Endonuclease G is an apoptotic Dnase when released from mitochondria. Nature 2001;412:95–99.
Li H, Kolluri SK, Gu J et al. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 2000;289:1159–1164.
Lin T, Genestier L, Pinkoski MJ et al. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. J Biol Chem 2000;275:8657–8663.
Liu XS, Kim CN, Yang JR et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996;86:147–157.
Lluis LM, Colell A, García-Ruiz C et al. Acetaldehyde impairs the mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 2003;124:452–463.
Lorenzo HK, Susin SA. Mitochondrial effectors in caspase-independent cell death. FEBS Lett 2004;557:14–20.
Malisan F, Franchi L, Tomassini B et al. Acetylation suppresses the proapoptotic activity of GD3 ganglioside. J Exp Med 2002;196:1535–1541.
Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2001;2:63–67.
Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signalling complexes. Cell 2003;114:181–190.
Nagai H, Matsumura K, Feng G, Kaplowitz N. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-induced apoptosis in cultured mouse hepatocytes. Hepatology 2002;36:55–64.
Nakagami M, Wheeler MD, Bradford BU et al. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem 2001;276:36664–36672.
Natori S, Rust C, Stadheim LM et al. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001;34:248–253.
Neuschwander-Tetri B, Caldwell SH. Nonalcoholic steato-hepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003;37:1202–1219.
Paris R, Morales A, Coll O et al. Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy. J Biol Chem 2002;277:49870–49876.
Rippo MR, Malisan F, Ravagnan L et al. GD3 ganglioside directly targets mitochondria in a bcl-2 controlled fashion. FASEB J 2000;14:2047–2054.
Roisin-Bouffay C, Luciani M-F, Klein G et al. Developmental cell death in dictyostelium does not require paracaspase. J Biol Chem 2004;279:11489–11494.
Rudiger HA, Clavien PA. Tumor necrosis factor alpha, but not Fas, mediates hepato cellular apoptosis in the murine ischemic liver. Gastroenterology 2002;122:202–210.
Scaffidi C, Fulda S, Srinivasan A et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998;17:1675–1687.
Scorrano L, Ashiya M, Buttle K et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell 2002;2:55–67.
Scorrano L, Petronilli P, DiLisa FP. Bernardi commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore. J Biol Chem 1999;274:22581–22585.
Serafin A, Rosello-Catafau J, Prats N et al. Ischemic preconditioning increases the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat. Am J Pathol 2002;161:587–601.
Susin SA, Lorenzo HK, Zamzami N et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441–446.
Van Loo G, van Gurp M, Depuydt B et al. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ 2002;9:20–26.
van Meer G, Lisman Q. Sphingolipid transport: rafts and translocators. J Biol Chem 2002;277:25855–25858.
Verhagen AM, Ekert PG, Pakusch M et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000;102:43–53.
Wallalch D, Varfolomeev EE, Malinin NL et al. Tumor necrosis factor receptor and Fas signalling mechanisms. Annu Rev Immunol 1999;17:331–367.
Zamzami N, Kroemer G. Apoptosis: mitochondrial membrane permeabilization — the (w)hole story? Current Biology 2003;13:R71–R73.
Zamzami N, Kroemer G. Mitochondria in apoptosis. How Pandora’s box opens. Nat Rev Mol Cell Biol 2001;2:67–71.
Zhao P, Kahorn TF, Slattery JT. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology 2002;36:326–335.
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Fernández-Checa, J.C., Garcia-Ruiz, C. (2005). Apoptosis and Mitochondria. In: Dufour, JF., Clavien, PA., Trautwein, C., Graf, R. (eds) Signaling Pathways in Liver Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27194-5_31
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