Magnetic Resonance of Myelination and Myelin Disorders

1. Front Matter

   Pages I-XVI

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2. Myelin and White Matter

   Pages 1-19

3. Classification of Myelin Disorders

   Pages 20-24

4. Selective Vulnerability

   Pages 25-36

5. Myelination and Retarded Myelination

   Pages 37-65

6. Lysosomes and Lysosomal Disorders

   • R.A. Wevers, V. Gieselmann

   Pages 66-73

7. Metachromatic Leukodystrophy

   Pages 74-81

8. Multiple Sulfatase Deficiency

   Pages 82-86

9. Globoid Cell Leukodystrophy: Krabbe Disease

   Pages 87-95

10. GM1 Gangliosidosis

    Pages 96-102

11. GM2 Gangliosidosis

    Pages 103-111

12. Fabry Disease

    Pages 112-118

13. Fucosidosis

    Pages 119-122

14. Mucoplysaccharidoses

    Pages 123-132

15. Free Sialic Acid Storage Disorder

    Pages 133-136

16. Neuronal Ceroid Lipofuscinoses

    Pages 137-146

17. Adult Polyglucosan Body Disease

    Pages 147-150

18. Peroxisomes and Peroxisomal Disorders

    • R.J.A. Wanders

    Pages 151-153

19. Peroxisome Biogenesis Defects

    Pages 154-166

20. Peroxisomal D-Bifunctional Protein Deficiency

    Pages 167-171

Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical abnormalities, and provided us with essential and unpublished f- and cellular processes underlying myelin disorders. ures: our friends Susan Blaser,from the Hospital for This immense progress has prompted us to embark Sick Children in Toronto,and Zoltán Patay,from the upon the enormous task of rewriting the previous King Faisal Hospital in Riyadh. edition and adding 40 chapters. In doing so we have Many people at the VU University Medical Center tried to cover most white matter disorders,hereditary have been of great technical help to us in producing and acquired,and to present a collection of images to high quality images and in providing secretarial illustrate the field to the fullest possible extent. This assistance. The contributions of these people are edition will therefore be more complete than the pre- mentioned separately in the acknowledgements.

• biochemistry
• classification
• magnetic resonance spectroscopy
• neurology
• radiology

From the reviews of the third edition:

"This book provides a comprehensive, lucid description of particularly challenging clinical entities. With the third edition, the authors have greatly broadened an excellent reference; I would recommend this book for any practicing radiologist faced with challenging MR examinations of the adult or pediatric brain." (Doody's Publisher's Club; Reviewer: Edward H. Herskovits, University of Pennsylvania Medical Center).

"What a fabulous book! … The contents describe in great depth all white matter disorders known today, both adult and paediatric, both inherited and acquired. … This is most definitely a reference book – a terrific reference book. … It is highly recommended – a must for neuroradiology/neurology, both adult and paediatric. Both departments are incomplete without it. I have never so strongly endorsed the purchase of a book. I am both grateful and delighted to have had the opportunity to review it." (Shelley Renowden, Journal of Neurology, Vol. 253, 2006)

• Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands

  Marjo S. Knaap

• Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands

  Jaap Valk

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