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HDV Ribozymes

  • Chapter
Hepatitis Delta Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 307))

Abstract

The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants. HDV ribozymes have provided a tractable system for studying the mechanism of catalytic RNA, and results of biochemical and structural studies on the HDV ribozymes, from a number of labs, have enhanced our understanding and expanded our thinking about the potential for catalytic roles of RNA side chains. The results of these studies are consistent with models suggesting that both an active-site cytosine and a divalent metal ion have catalytic roles in facilitating the cleavage reaction in the HDV ribozymes. Despite recent advances, details about the catalytic mechanism of the HDV ribozyme continue to be debated, and these ribozymes should serve as a good system for further study.

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Authors and Affiliations

  1. Department of Biochemistry, Duke University Medical Center, Durham, NC, USA

    M. D. Been

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  1. M. D. Been
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Editors and Affiliations

  1. Department of Microbiology and Immunology, Georgetown University, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    John L. Casey Ph.D.

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Been, M.D. (2006). HDV Ribozymes. In: Casey, J.L. (eds) Hepatitis Delta Virus. Current Topics in Microbiology and Immunology, vol 307. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29802-9_3

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