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Neuroscience of Aggression pp 45–71Cite as

Neurogenetics of Aggressive Behavior: Studies in Primates

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 17))

Abstract

Aggressive behavior can have adaptive value in certain environmental contexts, but when extreme or executed inappropriately, can also lead to maladaptive outcomes. Neurogenetic studies performed in nonhuman primates have shown that genetic variation that impacts reward sensitivity, impulsivity, and anxiety can contribute to individual differences in aggressive behavior. Genetic polymorphisms in the coding or promoter regions of the Mu-Opioid Receptor (OPRM1), Corticotropin Releasing Hormone (CRH), Monoamine Oxidase A (MAOA), Dopamine D4 Receptor (DRD4), and Serotonin Transporter (SLC6A4) genes have been shown to be functionally similar in humans and rhesus macaques and have been demonstrated to contribute to individual differences in aggression. This body of literature suggests mechanisms by which genetic variation that promotes aggressivity could simultaneously increase evolutionary success while making modern humans more vulnerable to psychopathology.

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Authors and Affiliations

  1. Section of Comparative Behavioral Genomics, Laboratory of Neurogenetics, NIH/NIAAA, Rockville, MD, USA

    Christina S. Barr & Carlos Driscoll

Authors
  1. Christina S. Barr
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  2. Carlos Driscoll
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Correspondence to Christina S. Barr .

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Editors and Affiliations

  1. Moses Hunt Professor of Psychology, Psychiatry, Pharmacol & Neurosci, Tufts University, Medford, Massachusetts, USA

    Klaus A. Miczek

  2. Dept of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

    Andreas Meyer-Lindenberg

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Barr, C.S., Driscoll, C. (2013). Neurogenetics of Aggressive Behavior: Studies in Primates. In: Miczek, K., Meyer-Lindenberg, A. (eds) Neuroscience of Aggression. Current Topics in Behavioral Neurosciences, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2013_267

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