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Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy pp 17–24Cite as

Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 135))

The embryonic development of the lymphatic vascular system starts considerably later than the blood vascular system. In chick embryos, the first blood vessels can be seen after 1 day of incubation, whereas morphological evidence for lymphatic endothelial cells (LECs) is present around day 5.However, with specific marker molecules, such as the transcription factor Prox1, LEC precursors can be identified in day-3.5 embryos. In the mouse, blood vessel development starts at embryonic day (ED) 7.5, whereas the anlagen of lymph vessels can be seen in the jugular region at ED 10. In human embryos there is a period of 3–4 weeks between the appearance of the first blood vascular endothelial cells (BECs) and LECs.

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Author information

Authors and Affiliations

  1. Children's Hospital, Pediatrics I, University of Goettingen, Robert-Koch-Strasse 40, 37075, Goettingen, Germany

    Jörg Wilting PhD, Maria Papoutsi PhD, Kerstin Buttler DB & Jürgen Becker MD

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  1. Jörg Wilting PhD
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  2. Maria Papoutsi PhD
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  3. Kerstin Buttler DB
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  4. Jürgen Becker MD
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Editor information

Editors and Affiliations

  1. University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, 94143, San Francisco, CA, USA

    Stanley P. L. Leong MD, FACS

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Wilting, J., Papoutsi, M., Buttler, K., Becker, J. (2007). Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis. In: Leong, S.P.L. (eds) Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy. Cancer Treatment and Research, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69219-7_2

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  • DOI: https://doi.org/10.1007/978-0-387-69219-7_2

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-0-387-69219-7

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