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History of Orthopedic Oncology in the United States

Progress from the Past, Prospects for the Future

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Pediatric and Adolescent Osteosarcoma

Part of the book series: Cancer Treatment and Research ((CTAR,volume 152))

Abstract

Orthopedic oncology in the United States has its roots in European medicine of the 1800s in which sarcomas were first classified on the basis of their gross characteristics (1804) and amended on the basis of their histologic features (1867). Surgical management, local excision, with unacceptable mortality gave way to amputation in the 1870s and remained so, until limb-sparing resection was cautiously embarked upon in the mid 1900s. Nonsurgical adjuvant was first devised in the 1880s (as Coley’s toxins) but remained largely ineffective until the advent of chemotherapy in the 1970s. The combination of these in the last 30 years, together with vastly improved staging and reconstructive techniques has led to the current preponderance of limb-salvaging surgery and greatly improved survival rates. Their application has been greatly enhanced by the development of Orthopedic oncology fellowships, formation of Orthopedic oncology societies, and the institution of federally funded regional cancer centers with the formation of multidisciplinary sarcoma treatment teams.

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Authors and Affiliations

  1. Departments of Orthopaedics and Pathology, College of Medicine, University of Florida, Gainesville, FL, USA

    William F. Enneking

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  1. William F. Enneking
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Correspondence to William F. Enneking .

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Editors and Affiliations

  1. MD Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030-4095, U.S.A.

    Norman Jaffe

  2. Dept. Medical Oncology, Norwegian Radium Hospital, Ullernschaussee 70, Oslo, 0310, Norway

    Oyvind S. Bruland

  3. Orthopädische Klinik, Olgahospital, Bismarckstraße 8, Stuttgart, 70176, Germany

    Stefan Bielack

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Enneking, W.F. (2009). History of Orthopedic Oncology in the United States. In: Jaffe, N., Bruland, O., Bielack, S. (eds) Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0284-9_32

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  • DOI: https://doi.org/10.1007/978-1-4419-0284-9_32

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  • Online ISBN: 978-1-4419-0284-9

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