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Calcium-Sensing Receptor pp 203–226Cite as

Alternative Agonists and Modulators: Evidence that the Calcium-Sensing Receptor is a Multi-Modal Sensor

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Part of the book series: Endocrine updates ((ENDO,volume 19))

Abstract

New information indicates that the calcium-sensing receptor (CaR) is a multi-modal sensor that integrates signals from various metabolic inputs (See Table 1). These findings suggest that the CaR is not only as a regulator of systemic calcium homeostasis but also mediates cellular responses to other important metabolic modalities, perhaps contributing to other biochemical feedback loops. Depending on the composition of the local extracellular milieu, the CaR can sense variations in extracellular levels of:

  • • Ca2+

  • • other divalent and multi-valent cations, especially Mg2+ and polyamines

  • • ionic strength (NaCl)

  • • pH

  • 204-1

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Authors and Affiliations

  1. Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Stephen J. Quinn Ph.D.

  2. School of Molecular and Microbial Biosciences (G08), University of Sydney, NSW, 2006, Australia

    Arthur D. Conigrave Ph.D., F.R.A.C.P.

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Editors and Affiliations

  1. Endocrine-Hypertension Division Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Naibedya Chattopadhyay  & Edward M. Brown  & 

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Quinn, S.J., Conigrave, A.D. (2003). Alternative Agonists and Modulators: Evidence that the Calcium-Sensing Receptor is a Multi-Modal Sensor. In: Chattopadhyay, N., Brown, E.M. (eds) Calcium-Sensing Receptor. Endocrine updates, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9256-7_9

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