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Mast Cell Biology pp 162–185Cite as

The Mast Cell in Innate and Adaptive Immunity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 716))

Abstract

Mast cells (MCs) were once considered only as effector cells in pathogenic IgE- and IgG-mediated responses such as allergy. However, developments over the last 15 years have suggested that MCs have evolved in vertebrates as beneficial effector cells that are involved in the very first inflammatory responses generated during infection. This pro-inflammatory environment has been demonstrated to be important for initiating innate responses in many different models of infection and more recently, in the development of adaptive immunity as well. Interestingly this latter finding has led to the discovery that small MC-activating compounds can behave as adjuvants in vaccine formulations. Thus, our continued understanding of the MC in the context of infectious disease is likely to not only expand our scope of the MC in the normal processes of immunity, but provide new therapeutic targets to combat disease.

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Authors and Affiliations

  1. Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher P. Shelburne

  2. Departments of Pathology, Immunology, and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

    Soman N. Abraham

  3. Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore

    Soman N. Abraham

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  1. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    Alasdair M. Gilfillan PhD  & Dean D. Metcalfe MD  & 

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© 2011 Landes Bioscience and Springer Science+Business Media

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Shelburne, C.P., Abraham, S.N. (2011). The Mast Cell in Innate and Adaptive Immunity. In: Gilfillan, A.M., Metcalfe, D.D. (eds) Mast Cell Biology. Advances in Experimental Medicine and Biology, vol 716. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9533-9_10

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