Abstract
In 6 healthy, young volunteers the kinetics of L-tryptophan (TRP) following 3 different single oral doses (1.5, 3, 6 g) simultaneously with urinary tryptamine (TA) excretion were examined. Blood and urine samples were collected hourly before and for 14 h after TRP. TRP in plasma and TA in urine were analysed by specific and sensitive HPLC methods using UV and fluorometric detection, respectively. The measurements were repeated in one volunteer after pretreatment with the decarboxylase inhibitor benserazide (3 × 125 mg/d for 15 days), and in 2 volunteers after pretreatment with the selective and reversible inhibitor of MAO-A, brofaremine (150 mg/d for 10 days).
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References
BALOH, R. W., DIETZ, J. and SPOONER, J.W. (1982) Myoclonus and ocular oscillations induced by L-tryptophan. Ann. Neurol. 2, 95–97.
BIECK, P. R., NILSSON, E., SCHICK, C., WALDMEIER, P.C. and LAUBER, J. (1984) Urinary excretion of tryptamine in comparison to normetanephrine and beta-phenylethylamine in human volunteers after subchronic treatment with different monoamine oxidase inhibitors. In: Neurobiology of the Trace Amines (BOULTON, A.A., BAKER, G.B., DEWHURST, W.G. and SANDLER, M. ed.) The HUMANA Press.
DeQUATTRO, V. and SJOERDSMA, A. (1967) Origin of urinary tyramine and tryptamine. Clin Chim Acta 16, 227–233.
DURDEN, D.A. and PHILIPS, S.R. (1980) Kinetic measurements of the turnover rates of phenylethylamine and tryptamine in vivo in the rat brain. J Neurochem. 34, 1725–1732.
GARRICK, N.A., SCHEININ, M., CHANG, W., LINNOILA, M. AND MURPHY, D. (1984) Differential effects of clorgyline on catecholamine and indoleamine metabolites in the cerebrospinal fluid of rhesus monkeys. Biochem Pharmacol. 33, 1423–1427.
GERSON, S.C. and BALDESSARINI, R.J. (1980) Motor effects of serotonin in the central nervous system. Life Sci. 27, 1435–1451.
GLASSMAN, A.H. and PLATMAN, S.R. (1969) Potentiation of a monoamine oxidase inhibitor by tryptophan. J Psychiatr. Res. 7, 83–88.
GREEN, A.R., ARONSON, J.K., CURZON, G. and WOODS, H.F. (1980) Metabolism of an oral tryptophan load. I Effects of dose and pretreatment with tryptophan. Br. J. clin. Pharmacol. 10, 603–610.
GRUSHKA, E. and KITKA, E.J. (1977) Tryptophan and kynurenine determination in untreated urine by reversed-phase high-pressure liquid chromatography. J. Chromatogr. 143, 51–56.
JONES, R.S.G. (1982) Tryptamine: A neuromodulator or neurotransmitter in mammalian brain? Progress in Neurobiology 19, 117–139.
MARSDEN, C.A. and CURZON, G. (1978) The contribution of tryptamine to the behavioral effects of L-trypthophan in tranylcypromine-treated rats. Psychopharmacology 57, 71–76
NILSSON, E. (1985) Determination of tryptamine in urine by high-performance liquid chromatography with fluorometric detection. Internal Report T 9, CIBA-GEIGY, HPI Tübingen.
OATES, J.A. and SJOERDSMA, A. (1966) Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor. Neurology 10, 1076–1078.
PHILIPS, S.R. (1984) Analysis of trace amines: Endogenous levels and the effects of various drugs on tissue concentrations in the rat. In: Neurobiology of the Trace Amines (BOULTON, A.A., BAKER, G.B., DEWHURST, W.G. and SANDLER, M. ed.) The HUMANA Press.
PRICE, L.H., CHARNEY, D.S. and HENINGER, G. (1984) Effects of i.v. L-tryptophan during tranylcypromine treatment of depression. Abstract from ‘American College of Neuropsychopharmacology’. Vanderbilt, 1984.
SJOERDSMA, A., OATES, J.A., ZALTZMANN, P. and UDENFRIEND, S. (1959). Identification and assay of urinary tryptamine: Application as an index of monoamine oxidase inhibition in man. J. Pharmacol. Exp. Therap. 126, 83–88.
THOMAS, J.M. and RUBIN, E.H. (1984) Case report of toxic reaction from a combination of tryptophan and phenelzine. Am. J. Psychiatry 141, 2, 281–283.
WARSH, J.J., COSCINA, D.V., GODSE, D.D. and CHAN, P.W. (1979) Dependance of brain tryptamine formation on tryptophan availability. J. Neurochem. 32, 1191–1196.
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© 1985 The Human Press Inc.
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Wollmann, H., Nilsson, E., Antonin, K.H., Bieck, P.R. (1985). Tryptamine Kinetics in Human Volunteers. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_37
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DOI: https://doi.org/10.1007/978-1-4612-5010-4_37
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