Abstract
The presence of neural tissues in human teratomas is of great clinicopathological value for the following reasons:
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1.
Neuroectodermal derivatives constitute one of the most commonly differentiated tissues in a teratoma. In practice, the majority of teratoid neoplasms yield neural tissues if adequately sampled (Willis, 1971).
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2.
The differentiation pattern of the nervous tissue found in teratomas is a good indicator of the overall maturity of the neoplasm. The current clinicopathological evaluations of teratomas are based on the amount of immature tissue, atypicality, and the proliferative capacity of embryonal tissues, especially of their neural components (Thurlbeck and Scully, 1960; Norris et al., 1976).
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3.
The presence of multiple neural elements and structures in different stages of ontogenesis mimics normal embryogenesis, and thus may shed some light on currently obscure embryological problems.
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4.
Large areas of neural tissue in immature teratomas resemble the morphology of common (glioma) and rare (medullo-epithelioma) tumors of the nervous system and can establish interrelations that may be of use in determining the histogenesis of some central nervous system tumors.
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Nogales, F.F., Aguilar, D. (1983). Neural Tissues in Human Teratomas. In: Damjanov, I., Knowles, B.B., Solter, D. (eds) The Human Teratomas. Contemporary Biomedicine, vol 3. Humana Press. https://doi.org/10.1007/978-1-4612-5628-1_7
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DOI: https://doi.org/10.1007/978-1-4612-5628-1_7
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