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Peritoneal mesothelioma: Treatment approach based on natural history

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Peritoneal Carcinomatosis: Drugs and Diseases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 81))

Abstract

Peritoneal mesothelioma is a rare tumor that is considered a terminal disease with only palliative treatment options. The natural history and actual incidence of disease are poorly documented because most reports include pleural and peritoneal mesothelioma together as a single disease. The estimated incidence of both pleural and peritoneal mesothelioma in the United States in 1975 was 2.2 cases per million population [1]. According to the experience at the University of Minnesota, the incidence of the disease has been on the rise in last few decades, probably due to more precise diagnosis [2]. Now it would be reasonable to estimate that 2,200 new cases (range 1,000–3,000+) of mesothelioma occur in the United States annually [3]. In most reports peritoneal and pleural mesotheliomas are considered as a single entity. Pleural mesothelioma is encountered more often and constitutes 60–90 percent of all cases [4,5]. Nevertheless, it has been reported that the natural history and prognosis of peritoneal and pleural mesotheliomas differ somewhat. Antman and colleagues [4,5] suggested that patients with peritoneal mesothelioma survive better. At autopsy tumor remained confined to the abdomen in two thirds of the cases and in 78 percent of them death was a direct result of complications of intraabdominal disease.

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Authors
  1. Andrew M. Averbach
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  2. Paul H. Sugarbaker
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Editors and Affiliations

  1. Washington Cancer Institute, Washington Hospital Center, 110 Irving Street, NW, Washington, D.C., 20010, USA

    Paul H. Sugarbaker M.D., F.A.C.S.

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Averbach, A.M., Sugarbaker, P.H. (1996). Peritoneal mesothelioma: Treatment approach based on natural history. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Drugs and Diseases. Cancer Treatment and Research, vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1245-1_17

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  • DOI: https://doi.org/10.1007/978-1-4613-1245-1_17

  • Publisher Name: Springer, Boston, MA

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