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Current Topics in Innate Immunity II pp 207–221Cite as

Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

Although nuclear factor-κB (NF-κB) is generally considered to be a pro-inflammatory transcription factor, recent studies indicate that it also plays a critical role in the development of an anti-inflammatory T cell subset called regulatory T (Treg ) cells. Two NF-κB proteins, c-Rel and p65, drive the development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. Consequently, c-Rel -deficient mice have marked reductions in Treg cells, and c-Rel -deficient T cells are compromised in Treg cell differentiation. However, with the exception of Foxp3, most NF-κB target genes in immune cells are pro-inflammatory. These include several Th17 -related cytokine genes and the retinoid-related orphan receptor-γ (Rorg or Rorc) that specifies Th17 differentiation and lineage-specific function. T cells deficient in c-Rel or p65 are significantly compromised in Th17 differentiation, and c-Rel -deficient mice are defective in Th17 responses. Thus, NF-κB is required for the development of both anti-inflammatory Treg and pro-inflammatory Th17 cells.

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  1. Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, 422 Curie Blvd., 19104, Philadelphia, PA, USA

    Qingguo Ruan & Youhai H. Chen

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  1. Qingguo Ruan
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  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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© 2012 Springer Science+Business Media, LLC

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Ruan, Q., Chen, Y.H. (2012). Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_12

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