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Stem Cells and Spinal Cord Injury Repair

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Regenerative Biology of the Spine and Spinal Cord

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 760))

Abstract

Spinal cord injury (SCI) has remained a challenging area for scientists and clinicians due to the adverse and complex nature of its pathobiology. To date, clinical therapies for debilitating SCI are largely ineffective. However, emerging research evidence suggests that repair of SCI can be promoted by stem cell-based therapies in regenerative medicine. Over the past decade, therapeutic potential of different types of stem cells for the treatment of SCI have been investigated in preclinical models. These studies have revealed multiple beneficial roles by which stem cells can improve the outcomes of SCI. This chapter will summarize the recent advances in the application of stem cells in regenerative medicine for the repair of SCI.

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Authors and Affiliations

  1. Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada

    Soheila Karimi-Abdolrezaee & Eftekhar Eftekharpour

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  1. Soheila Karimi-Abdolrezaee
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Editors and Affiliations

  1. Division of Neurosurgery, City of Hope Cancer Center and Beckman Research Institute, Los Angeles, California, USA

    Rahul Jandial MD, PhD  & Mike Y. Chen MD, PhD  & 

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Karimi-Abdolrezaee, S., Eftekharpour, E. (2012). Stem Cells and Spinal Cord Injury Repair. In: Jandial, R., Chen, M.Y. (eds) Regenerative Biology of the Spine and Spinal Cord. Advances in Experimental Medicine and Biology, vol 760. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4090-1_4

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