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Core Concepts in Parenchymal Kidney Disease pp 329–339Cite as

Acute Interstitial Nephritis

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Abstract

Acute Interstitial nephritis is an inflammatory parenchymal renal disease with major involvement of the tubules and interstitial regions of the kidney. It encompasses many etiologies including idiopathic disease, and forms associated with the use of medications, infectious agents, and autoimmune disorders. Although the mechanisms of renal damage may vary from one etiology to another, cellular interstitial infiltrates and “tubulitis” are hallmarks of the disease process. Clinical features also vary, but most patients present with acute kidney injury which is often non-oliguric in nature. In many medication-related forms the clinical picture is characterized by rash, fever, and eosinophilia, while the urinary findings are of hematuria and eosinophiluria. Therapy must be directed at the underlying etiology of the disease process, but use of steroids and perhaps other immunosuppressives appear to be of value in some patients.

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Authors and Affiliations

  1. Clinical Nephrology, Department of Medicine, Columbia University Medical Center, New York, NY, USA

    Gerald B. Appel M.D.

  2. Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA

    Alice S. Appel Ph.D.

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  1. Gerald B. Appel M.D.
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  2. Alice S. Appel Ph.D.
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Correspondence to Gerald B. Appel M.D. .

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Editors and Affiliations

  1. Div. Nephrology & Hypertension, Mayo Clinic Dept. Internal Medicine, Rochester, Minnesota, USA

    Fernando C. Fervenza

  2. Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Julie Lin

  3. Mayo Clinic, Rochester, Minnesota, USA

    Sanjeev Sethi

  4. Renal Division, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts, USA

    Ajay K. Singh

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© 2014 Springer Science+Business Media New York

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Appel, G.B., Appel, A.S. (2014). Acute Interstitial Nephritis. In: Fervenza, F., Lin, J., Sethi, S., Singh, A. (eds) Core Concepts in Parenchymal Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8166-9_23

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  • DOI: https://doi.org/10.1007/978-1-4614-8166-9_23

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8165-2

  • Online ISBN: 978-1-4614-8166-9

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