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Progress in Cell Cycle Research pp 21–32Cite as

Regulation of p70s6k/p85s6k and its role in the cell cycle

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Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Two to three-fold increases in the rate of protein synthesis are required both to enter the G1 phase of the cell cycle from G0 and to proceed to S phase in response to growth factors and mitogens. This increase is in part regulated via multiple phosphorylation of the 40S ribosomal protein S6 by the mitogen-stimulated p70s6k/p85s6k. At the protein synthesis level this event appears to be involved in specifically increasing the efficiency of translation of a family of essential mRNAs containing a polypyrimidine tract at their 5′ transcriptional start site. The activation of p70s6k/p85s6k and maintenance of its activity throughout G1 is controlled via multiple phosphorylation events mediated by a complex signalling network acting on distinct sets of phosphorylation sites.

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  1. Friedrich Miescher Institute, PO 2543, CH-4002, Basel, Switzerland

    Richard B. Pearson & George Thomas

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    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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Pearson, R.B., Thomas, G. (1995). Regulation of p70s6k/p85s6k and its role in the cell cycle. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_3

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