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Endocrine Neoplasms pp 335–346Cite as

Insulinoma and other islet-cell tumors

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 89))

Abstract

The recognition of islet-cell tumors of the pancreas histologically preceded their clinical identification by many decades. In the case of insulinoma, its existence was predicted from the occurrence of ‘insulin reactions’ in nondiabetic persons [1]; in the case of other islet-cell tumors, their existence (glucagonoma, somatostatinoma, VIPoma, PPoma) followed the development of the ability to measure in the circulation the polypeptides that were secreted in excess. In most (somatostatinoma, glucagonoma, VIPoma) but not (PPoma) all instances, a clinical syndrome could be identified with the elevated levels of specific polypeptides.

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Authors
  1. F. John Service
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Editors and Affiliations

  1. Laboratory of Endocrine Oncology Massachusetts General Hospital, Harvard Medical School, Jackson 1021, Boston, MA, 02114, USA

    Andrew Arnold M.D. (Chief, Associate Professor of Medicine) (Chief, Associate Professor of Medicine)

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© 1997 Springer Science+Business Media New York

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John Service, F. (1997). Insulinoma and other islet-cell tumors. In: Arnold, A. (eds) Endocrine Neoplasms. Cancer Treatment and Research, vol 89. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6355-6_15

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  • DOI: https://doi.org/10.1007/978-1-4615-6355-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7919-5

  • Online ISBN: 978-1-4615-6355-6

  • eBook Packages: Springer Book Archive

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