Abstract
Indirect evidence suggests that cardiac function may be affected by phosphate depletion (PD). Coburn and Massry (l) found that glomerular filtration rate is reduced during phosphate depletion and it returned to normal with phosphate repletion. They suggested that this phenomenon may be related to alteration in cardiac function. O’Connor, Wheeler and Bethune (2) evaluated the effect of PD on cardiac function in seven patients. They found that stroke work was reduced but returned to normal after phosphate administration. Cardiac output, as well as left ventricular stroke volume, were decreased and correlated with the rise in pulmonary artery wedge pressures. The authors showed that with the correction of the hypophosphatemia, left ventricular stroke volume improved and pulmonary artery wedge pressure decreased. Their studies were the first direct demonstration that phosphate depletion may affect cardiac function in man.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.W. Coburn, and S.G. Massry, Changes in serum and urinary calcium during phosphate depletion: Studies on mechanisms, J. Clin. Invest. 49:1073 (1970).
L.R. O’Connor, W.S. Wheeler and J.E. Bethune, Effect of hypophosphatemia on myocardial performance in men, New Engl. J. Med. 294:901 (1977).
T.J. Fuller, W.W. Nichols, B.J. Brenner and J.C. Peterson, Reversible depression in myocardial performance in dogs with experimental phosphorus deficiency, J. Clin. Invest. 62:1194 (1978).
J.R. Darsee and D.O. Nutter, Reversible severe congestive cardiomyopathy in three cases of hypophosphatemia, Ann. Int. Med. 89:867 (1978).
O.H. Lowry and J.B. Passanneau, A flexible system for enzymatic analysis, Academic Press, New York, p 123 (1972).
S.P. Bessman, P.J. Geiger, T. Sung-Cho-Lu and E.R.B. McCabe, Separation and automated analysis of phosphorylated metabolic intermediates. Analytical Biochemistry 59:533 (1974).
W.C.T. Yang, P.J. Geiger and S.P. Bessman, Formation of creatine phosphate from creatine and 32P-labeled ATP by isolated rabbit heart mitochondria. Biochem. Biophys. Res. Com. 76:882 (1977).
B. Chance and G.R. Williams, Respiratory enzymes in oxidative phosphorylation. I. Kinestics of oxygen utilization, J. Biol. Chem. 217:383 (1955).
C.B. Oscai and J.O. Holloszy, Biochemical adaptation in muscle: II. Response of mitochondrial adenosinetriphosphatase, creatine Phosphokinase and adenylate kinase activities in skeletal muscle to exercise, J. Biol. Chem 246:6968 (1971).
R.J. Solaro, D.C. Pang and F.N. Briggs, The purification of cardiac myofibrils with triton X-100, Biochem. Biophys. Acta. 245:259 (1971).
S.P. Bessman and P.J. Geiger, Transport of energy in muscle: The phosphorylcreatine shuttle, Science 211:448 (1981).
V.A. Saks, V.V. Kupriyanov and G. Elizarova, Studies of energy transport in heart cells, J. Biol. Chem. 255:755 (1980).
M.W. Seraydian and L. Artaza, Regulation of energy metabolism by creatine in cardiac and skeletal muscle cells in culture, J. Mole. Cell. Cardiol. 8:669 (1976).
B.J. Walker, Creatine biosynthesis, regulation and function, In Advances in Enzynology, Ed. A. Meisner, J. Wiley & Sons, New York, V50, p 177 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Brautbar, N., Baczynski, R., Carpenter, C., Massry, S.G. (1982). Effects of Phosphate Depletion on the Myocardium. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_26
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4259-5_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4261-8
Online ISBN: 978-1-4684-4259-5
eBook Packages: Springer Book Archive