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Effects of Hypertension on Arterial Gene Expression and Atherosclerosis

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Cellular and Molecular Mechanisms in Hypertension

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 308))

Abstract

Hypertension may induce major changes in the arterial intima and media which may lead to arterial injury and atherosclerosis. Although the mechanisms involved in these alterations have not been clearly defined, recent studies in our own and other laboratories have demonstrated changes in gene expression of certain growth factors and functionally important proteins in response to blood pressure elevation or to vasoactive agents. This paper reviews these observations and also summarizes some recent data on the effects of antihypertensive drugs on atherogenesis.

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Authors and Affiliations

  1. Boston University School of Medicine, Boston, MA, 02118, USA

    Aram V. Chobanian

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  1. Aram V. Chobanian
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Editors and Affiliations

  1. Bockus Research Institute, The Graduate Hospital and Department of Physiology, The University of Pennsylvania, 19104, Philadelphia, PA, USA

    Robert H. Cox

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© 1991 Plenum Press, New York

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Chobanian, A.V. (1991). Effects of Hypertension on Arterial Gene Expression and Atherosclerosis. In: Cox, R.H. (eds) Cellular and Molecular Mechanisms in Hypertension. Advances in Experimental Medicine and Biology, vol 308. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6015-5_4

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  • DOI: https://doi.org/10.1007/978-1-4684-6015-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6017-9

  • Online ISBN: 978-1-4684-6015-5

  • eBook Packages: Springer Book Archive

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