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Morphogenesis of Mammary Gland Development

  • Conference paper
Protecting Infants through Human Milk

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 554))

Abstract

Development of the mammary gland in females is a dynamic, orchestrated process that occurs throughout postnatal development. Initiated during embryogenesis, epithelial cells advance into the underlying stromal matrix to form a primitive rudimentary structure. With the onset of puberty this anlage then responds to hormonal and local cues to rapidly establish a ductal network. Whereas in mice this network is relatively simple, in humans there is significantly more branching morphogenesis to develop terminal duct lobular unit structures. With the onset of pregnancy and associated changes in the hormonal and local environment, alveolar development progresses to establish a gland that is densely filled with alveolar structures by the end of pregnancy. Concomitantly, mammary epithelial cells within the gland begin to attain their unique ability to synthesize various milk constituents, such that by parturition, functional lactogenesis can be realized.

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Author information

Authors and Affiliations

  1. Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, 570 Main Street, Burlington, VT, 05405, USA

    Russell C. Hovey & Josephine F. Trott

Authors
  1. Russell C. Hovey
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  2. Josephine F. Trott
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Editor information

Editors and Affiliations

  1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    Larry K. Pickering MD

  2. Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

    Ardythe L. Morrow PhD

  3. Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico

    Guillermo M. Ruiz-Palacios MD

  4. Schneider Children’s Hospital at North Shore, Manhasset, New York, USA

    Richard J. Schanler MD

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© 2004 Springer Science+Business Media New York

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Hovey, R.C., Trott, J.F. (2004). Morphogenesis of Mammary Gland Development. In: Pickering, L.K., Morrow, A.L., Ruiz-Palacios, G.M., Schanler, R.J. (eds) Protecting Infants through Human Milk. Advances in Experimental Medicine and Biology, vol 554. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4242-8_19

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  • DOI: https://doi.org/10.1007/978-1-4757-4242-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3461-1

  • Online ISBN: 978-1-4757-4242-8

  • eBook Packages: Springer Book Archive

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