Skip to main content
SpringerLink
Log in

Alterations in Receptors for Sensory Neuropeptides in Human Inflammatory Bowel Disease

  • Chapter
Sensory Nerves and Neuropeptides in Gastroenterology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 298))

Abstract

Glutamate and several neuropeptides are synthesized and released by subpopulations of primary afferent neurons. These sensory neurons play a role in regulating the inflammatory and immune responses in peripheral tissues. We have explored what changes occur in the location and concentration of receptor binding sites for sensory neurotransmitters in two human inflammatory diseases, ulcerative colitis and Crohn’s disease, using quantitative receptor autoradiography. The sensory neurotransmitter receptors included bombesin, calcitonin gene-related peptide-α, cholecystokinin, galanin, glutamate, somatostatin, neurokinin A (substance K), substance P, and vasoactive intestinal polypeptide. Of the nine receptor binding sites examined only binding sites for substance P and vasoactive intestinal peptide were significantly altered in the inflamed tissue. These data suggest that substance P is involved in regulating the inflammatory and immune responses in human inflammatory diseases and indicate a specificity of efferent action for each sensory neurotransmitter in peripheral tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

A:

artery

bas:

basal

BBS:

bombesin

bv:

blood vessel (arteriole or venule)

CCK:

cholecystokinin

CGRP:

calcitonin gene-related peptide-α

CM:

circular muscle of the muscularis externa

ct:

connective tissue

g:

germinal layer of a lymph nodule

GAL:

galanin

GLU:

glutamate

H-E:

hematoxylin and eosin

LM:

longitudinal muscle of the muscularis externa

lum:

luminal

Lym:

lymph nodule

Mc:

mucosa

Mc:

— b mucosa, basal aspect

Mc:

— l mucosa, luminal aspect

MM:

muscularis mucosa

MP:

myenteric plexus

musc:

muscle

p:

proliferative zone of a lymph nodule

SK:

substance K, neurokinin A, α-neurokinin, neuromedin L

SOM:

somatostatin

SP:

substance P

SubMc:

submucosa

U.C.:

ulcerative colitis

VIP:

vasoactive intestinal peptide

References

  1. Almy, T., 1980, Psychosocial aspects of chronic ulcerative-colitis and Crohn’s disease, in: “Inflammatory Bowel Disease”, J.B. Kirsner and R.G. Shorter, eds., Lea and Fibiger, Philadelphia.

    Google Scholar 

  2. Bar-Shavit, Z., Goldman, R., Stabinsky, Y., Gottlieb, P., Fridkin, M., Teichberg, V.I. and Blumberg, S., 1980, Enhancement of phagocytosis: a newly found activity for substance P residing in its N-terminal tetrapeptide sequence, Biochem. Biophys. Res. Commun., 94:1445.

    Article  PubMed  CAS  Google Scholar 

  3. Bartho, L., and Holzer, P., 1985, Search for a physiological role of substance P in gastrointestinal motility, Neuroscience, 16:1.

    Article  PubMed  CAS  Google Scholar 

  4. Bayliss, V.M., 1901, On the origin from the spinal cord of the vasodilator fibres of the hind limb, and on the nature of these fibres, J. Physiol. (Lond), 26:173.

    CAS  Google Scholar 

  5. Benjamin, N., Collery, C. T., Fuller, R. W., Larkin, S., and McEwan, S., 1987, The effects of calcitonin gene-related peptide and substance P on resistance and capacitance vessels, Br. J. Pharmacol., 90:39 (abstract).

    Google Scholar 

  6. Beuerman, R.W., and Schimmelpfennig, B., 1980, Sensory denervation of the rabbit cornea affects epithelial properties, Exp. Neurol., 69:196.

    Article  PubMed  CAS  Google Scholar 

  7. Bishop, A. E., Polak, J. M., Bryant, M. G., Bloom, S. R., and Hamilton, S., 1980, Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn’s disease, Gastroenterology, 9:853.

    Google Scholar 

  8. Brimijoin, S., Lundberg, J. M., Brodin, E., Hokfelt, T., and Nilsson, G., 1980, Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig, Brain Res., 191:443.

    Article  PubMed  CAS  Google Scholar 

  9. Buck, S.H., and Burks, T.F., 1983, Capsaicin; hot new pharmacological tool, Trends Pharm. Sci., 4:84.

    Article  CAS  Google Scholar 

  10. Burcher, E., Buck, S. H., Lovenberg, W., and O’Donohue T. L., 1986, Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder, J. Pharm. Exp. Ther., 236:819.

    CAS  Google Scholar 

  11. Burcher, E., Shults, C. W., Buck, S. H., Chase, T. N., and O’Donohue, T.L., 1984, Autoradiographic distribution of substance K binding sites in rat gastrointestinal tract: a comparison with substance P, Eur. J. Pharm., 102:561.

    Article  CAS  Google Scholar 

  12. Colpaert, F. C., Donnerer, J., and Lembeck, F., 1983, Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis, Life Sci., 32:1827.

    Article  PubMed  CAS  Google Scholar 

  13. Corey, L., and Spear, P.G., 1986, Infections with herpes simplex viruses, N. Engl. J. Med., 314:686.

    Article  PubMed  CAS  Google Scholar 

  14. Cowan, W.M., Gottlieb, D.I., Hendrickson, A.E., Price, J.L., and Woolsey, T.A., 1972, The autoradiographic demonstration of axonal connections in the central nervous system, Brain Res., 37:21.

    Article  PubMed  CAS  Google Scholar 

  15. Dale, H.H., 1935, Walter Ernest Dixon Memorial Lecture, Proc. R. Soc. Med. Therap., Sec.28:319.

    CAS  Google Scholar 

  16. Dalsgaard, C. J., Haegerstrand, A., Theodorsson-Norheim, E., Brodin, E., and Hokfelt, T., 1985, Neurokinin A-like immuno-reactivitiy in rat primary sensory neurons: coexistence with substance P, Histochemistry, 83:37.

    Article  PubMed  CAS  Google Scholar 

  17. Dalsgaard, C. J., Vincent, S. R., Hokfelt, T., Lundberg, J. M., Dahlstrom, A., Schultzberg, M., Dockray, C.J., and Cuello, A.C., 1982, Co-existence of cholecystokinin- and substance P-like peptides in neurons of the dorsal root ganglion of the rat, Neurosci. Lett., 33:159.

    Article  PubMed  CAS  Google Scholar 

  18. Debiasi, S., Vaneyck, S.L., Petrusz, P., and Rustioni, A., 1987, Glutamate and substance P co-exist in the same primary afferent terminal in the superficial laminae of the rat spinal dorsal horn, Neurosci. Abstr., 13:434.

    Google Scholar 

  19. Devillier, P., Weill, B., Renoux, M., Menkes, C., and Pradelles, P., 1987, Elevated levels of tachykinin-like immunoreactivity in joint fluids from patients with rheumatic inflammatory diseases, N. Engl. J. Med., 314:1323.

    Google Scholar 

  20. Eccles, J. C., 1957, “The Physiology of Nerve Cells,” Johns Hopkins Press, Baltimore.

    Google Scholar 

  21. Foreman, J., and Jordan, C., 1983, Histamine release and vascular changes induced by neuropeptides, Agents Actions, 13:105.

    Article  PubMed  CAS  Google Scholar 

  22. Franco, R., Costa, M., and Furness, J.B., 1979a, Evidence for the release of endogenous substance P from intestinal nerves, Naunyn-Schmiedeberg’s Arch. Pharmacol., 301:195.

    Google Scholar 

  23. Franco, R., Costa, M., and Furness, J.B., 1979b, Evidence that axons containing substance P in the guinea-pig ileum are of extrinsic origin, Naunyn-Schmiedeberg’s Arch. Pharmacol., 307:57.

    Article  CAS  Google Scholar 

  24. Furness, J., Papka, R. E., Delia, N. G., Costa, M., and Eskay, R.L., 1982, Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs, Neuroscience, 7:447.

    Article  PubMed  CAS  Google Scholar 

  25. Gallin, J. I., and Fauci, A. S., 1982, “Advances in Host Defense Mechanisms,” Vol. 1 Phagocytic Cells, Raven Press, New York.

    Google Scholar 

  26. Gamse, R., Holzer, P., and Lembeck, F., 1980, Decrease of substance P in primary afferent neurons and impairment of neurogenic plasma extravasation by capsaicin, Br. J. Pharmac, 68:207.

    Article  CAS  Google Scholar 

  27. Gaudreau, P., Quirion, R., St. Pierre, S., and Pert, C.B., 1983, Characterization and visualization of cholecystokinin receptors in rat brain using [3H]pentagastrin, Peptides, 4:755.

    Article  PubMed  CAS  Google Scholar 

  28. Gibbs, I. L., Furness, J.B., Costa, M., MacIntyre, I., Hillyard, C.J., and Girgis, S., 1985, Colocalization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs, Neurosci. Lettr., 57:125.

    Article  Google Scholar 

  29. Goedert, M., Mantyh, P. W., Emson, P. C., and Hunt, S. P., 1984, Inverse relationship between neurotensin receptors and neurotensin-like immunoreactivity in the cat striatum, Nature, 307:543.

    Article  PubMed  CAS  Google Scholar 

  30. Greenamyre, J.T., Young, A. B., and Penney, J. B., 1983, Quantitative autoradiography of L-[3H]glutamate binding in rat brain, Neurosci. Lett., 37:155.

    Article  PubMed  CAS  Google Scholar 

  31. Greenamyre, J.T., Young, A. B., and Penney, J. B., 1983, Quantitative autoradiography distribution of L-[3H]glutamate binding sites in rat central nervous system, J. Neurosci., 8:2133.

    Google Scholar 

  32. Hartung, H. P., and Toyka, K.V., 1983, Activation of macrophages by substance P: induction of oxidative burst and thromboxane release, Eur. J. Pharmacol., 89:301.

    Article  PubMed  CAS  Google Scholar 

  33. Hartung, H. P., Wolters, K., and Toyka, K.V., 1986, Substance P: binding properties and studies on cellular responses in guinea pig macrophages, J. Immunol., 136:856.

    Google Scholar 

  34. Herkenham, M., 1987, Mismatches between neurotransmitter and receptor localization in brain: observations and implications, Neuroscience, 23:1.

    Article  PubMed  CAS  Google Scholar 

  35. Hokfelt, T., Johansson, O., Ljungdalh, A., Lundberg, J.M., and Schultzberg, M., 1980, Peptidergic neurons, Nature, 284:515.

    Article  PubMed  CAS  Google Scholar 

  36. Hokfelt, T., Jellerth, J. O., Nilsson, G., and Pernow, B., 1975, Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons, Brain Res., 100:235.

    Article  PubMed  CAS  Google Scholar 

  37. Hua, X. Y., Theodorsson-Norheim, E., Brodin, E., Lundberg, J.M., and Hokfelt, T., 1985, Multiple tachykinins, neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea pig, Regulatory Peptides, 13:1.

    Article  PubMed  CAS  Google Scholar 

  38. Hylden, J.L.K., and Wilcox, G. L., 1981, Intrathecal substance P elicits a caudally directed biting and scratching behavior in mice, Brain Res., 217:212.

    Article  PubMed  CAS  Google Scholar 

  39. Jansco, N.A., Jansco-Gabor, A., and Szolcsanyi, J., 1967, Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin, Br. J. Pharmacol., 31:138.

    Google Scholar 

  40. Jansco, N. A., Jansco-Gabor, A., and Szolcsanyi, J., 1968, The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat, Br. J. Pharmac, 32:32.

    Google Scholar 

  41. Jansco, N. A., Kiraly, E., and Jansco-Gabor, A., 1980, Pharmacologically induced elective degeneration of chemosensitive primary sensory neurons, Nature, 270:741.

    Google Scholar 

  42. Jansco, N.A., Kiraly, E., and Jansco-Gabor, A., 1980, Chemosensitive pain fibers and inflammation, Int. J. Tiss. Reac., 2:57.

    Google Scholar 

  43. Jessel, T.M., and Iversen, L.L., 1977, Opiate analgesics inhibit substance P release from rat trigeminal nucleus, Nature, 268:549.

    Article  Google Scholar 

  44. Johnson, A. R., and Erdos, E.G., 1973, Release of histamine from mast cells by vasoactive peptides, Proc. Soc. Exp. Biol. Med., 142:1252.

    PubMed  CAS  Google Scholar 

  45. Ju, G., Hokfelt, T., Brodin, E., Fahrenkrug, J., Fischer, J. A., Frey, P., Elde, R.P., and Brown, J.C., 1987, Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal peptide- and cholecystokinin-immunoreactive ganglion cells, Cell Tissue Res., 247:417.

    Article  PubMed  CAS  Google Scholar 

  46. Koch, T.R., Carney, J.A., and Go, V.L.W., 1987, Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases, Dig. Diseases and Sciences, 32.369.

    Article  CAS  Google Scholar 

  47. Kuhar, M. J., 1985, The mismatch problem in receptor mapping studies, Trends Neurosci., 8:190.

    Article  CAS  Google Scholar 

  48. Langley, J. N., 1923, Antidromic action, J. Physiol.(Lond), 57:428.

    CAS  Google Scholar 

  49. Lembeck, F., Donnerer, J. and Colpaert, F. C., 1981, Increase of substance P in primary afferent nerves during chronic pain, Neuropeptides, 1:175.

    Article  CAS  Google Scholar 

  50. Lembeck, F., and Holzer, P., 1979, Substance P as a neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation, Naunyn-Schmiedeberg’s Arch. Pharmacol., 310:175.

    Article  CAS  Google Scholar 

  51. Levine, J. D., Clark, R., Devor, M., Helms, C., Moskowitz, M.A., Basbaum, A.I., 1985, Intraneuronal substance P contributes to the severity of experimental arthritis, Science, 226:547.

    Article  Google Scholar 

  52. Levine, J.D., Collier, D.H., Basbaum, A.I., Moskowitz, M.A., and Helms, C.A., 1985, Hypothesis: the nervous system may contribute to the pathophysiology of rheumatorid arthritis, J. Rheumatology, 12:410.

    Google Scholar 

  53. Levine, J. D., Dardick, S. J., Roizen, M. F., Helms, C., and Basbaum, A.I., 1986, Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis, J. Neurosci., 6:3423.

    PubMed  CAS  Google Scholar 

  54. Lewis, T., and Marvin, H. M., 1927, Observations relating to vasodilatation arising from antidromic impulses, to herpes zoster and trophic effects, Heart, 14:27.

    Google Scholar 

  55. Llewellyn-Smith, I.J., Furness, J.B., Murphy, R., O’Brien, P.E., and Costa, M., 1984, Substance P-containing nerves in the human small intestine: distribution, ultrastructure, and characterization of the immunoreactive peptide, Gastroenterology, 86:421.

    PubMed  CAS  Google Scholar 

  56. Lotz, M., Carson, D.A., Vaughan, J.H.,, 1987, Substance P activation of rheumatoid synoviocytes: Neural pathway in pathogenesis of arthritis, Science, 235:893.

    Article  PubMed  CAS  Google Scholar 

  57. Lundberg, J.M., Brodin, E., Hua, X., and Saria, A., 1984, Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea pig, Acta Physiol. Scand., 120:217.

    Article  PubMed  CAS  Google Scholar 

  58. Lundberg, J. M., Franco-Cereceda, A., Hua, X., Hokfelt, T., and Fischer, J.A., 1985, Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and broncho-constrictor effects of capsaicin, Eur. J. Pharmacology, 108:315.

    Article  CAS  Google Scholar 

  59. Lundberg, J.M., and Saria, A., 1983, Capsaicin-induced de-sensitization of the airway mucosa to cigarette smoke, mechanical and chemical irritants, Nature, 302:251.

    Article  PubMed  CAS  Google Scholar 

  60. Maggio, J.E., 1988, Tachykinins, Ann. Rev. Neurosci., 11:13.

    Article  PubMed  CAS  Google Scholar 

  61. Maggio, J. E., and Hunter, J. C., 1984, Regional distribution of kassinin-like immunoreactivity in rat central and peripheral tissues and the effect of capsaicin, Brain Res., 307:370

    Article  PubMed  CAS  Google Scholar 

  62. Mantyh, C. R., Gates, T. S., Zimmerman, R. P., Welton, M. L., Passaro, E.P.Jr., Vigna, S.R., Maggio, J.E., Kruger, L., and Mantyh, P.W., 1988, Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn Disease, Proc. Natl. Acad. Sci., 85:3235.

    Article  PubMed  CAS  Google Scholar 

  63. Mantyh, C. R., and Mantyh, P.W., 1985, Differential localization of cholecystokinin-8 binding sites in the rat vs the guinea pig brain, Eur. J. Pharmacol., 113:37.

    Article  Google Scholar 

  64. Mantyh, P. W., 1988, Autoradiographic localization and characterization of receptor binding sites in the brain and peripheral tissues, in: “Receptor Biochemistry and Methodology: Receptor Localization, Ligand Autoradiography,” Vol. 13, F.M. Leslie and C.A. Altar, eds., A.R. Liss, New York.

    Google Scholar 

  65. Mantyh, P.W., Goedert, M., and Hunt, S. P., 1984a, Autoradiographic visualization of receptor binding sites for substance P in the gastrointestinal tract of the guinea pig, Eur. J. Pharm., 100:133.

    Article  CAS  Google Scholar 

  66. Mantyh, P.W., and Hunt, S.P., 1985a, Autoradiographic visualization of [3H]-Substance P receptor binding sites in the rat and bovine spinal cord and the rat and cat spinal trigeminal nucleus pars caudalis and the effects of neonatal capsaicin, Brain Res., 332:315.

    Article  PubMed  CAS  Google Scholar 

  67. Mantyh, P. W., and Hunt, S. P., 1986, Changes in 3H-substance P receptor binding sites in the rat brain after kia-nic lesion of the corpus striatum, J. Neurosci., 6:1537.

    PubMed  CAS  Google Scholar 

  68. Mantyh, P. W., Hunt, S. P. and Maggio, J. E., 1984b, Substance P receptors: localization by light microscopic auto-radiograph in rat brain using [3H]-SP as the radioligand, Brain Res., 307:147.

    Article  PubMed  CAS  Google Scholar 

  69. Mantyh, P. W., Maggio, J. E., and Hunt, S. P., 1984c, The autoradiographic distribution of kassinin and substance K binding sites is different from the distribution of substance P binding sites in the rat brain, Eur. J. Pharmacol., 102:361.

    Article  PubMed  CAS  Google Scholar 

  70. Mantyh, P. W., Mantyh, C. R., Brecha, N. C., Kruger, L., and Sternini, C., 1985b), Autoradiographic localization of calcitonin gene-related peptide binding sites in the rat brain, guinea pig periphery and human spinal cord, Neurosci. Abstr., 11:145.

    Google Scholar 

  71. Mantyh, P. W., Mantyh, C.R., Gates, T., Vigna, S.R., and Maggio, J.E., 1988, Receptor binding sites for substance P and substance K in the Canine gastrointestinal tract and their possible role in inflammatory bowel disease, Neuroscience, 25:817.

    Article  PubMed  CAS  Google Scholar 

  72. Mantyh, P.W., Mantyh, C. R., and Maggio, J. E., 1987a, Heterogeneity of tachykinin receptors, in: “Substance P and Neurokinins,” James L. Henry, ed., Springer-Verlag, New York (in press).

    Google Scholar 

  73. Mantyh, P.W., Mantyh, C.R., Popper, P., Vigna, S.R., Kruger, L., Basbaum, A.I., Levine, J.D., and Maggio, J.E., 1987b, Receptors for sensory neuropeptides may be involved in the pathophysiology of rheumatoid arthritis, Soc. Neurosci. Abstr., 13:563.

    Google Scholar 

  74. Mantyh, P. W., Pinnock, R. D., Downes, C. P., Goedert, M., and Hunt, S.P., 1984d, Substance P receptors: correlation with substance P induced inositol phospholipid hydrolysis in the rat central nervous system, Nature, 309:795.

    Article  PubMed  CAS  Google Scholar 

  75. Marasco, W. A., Showell, H.J., and Becker, E.L., 1981, Substance P binds to the formaldehyde Chemotaxis receptor on the rabbit neutrophil, Biochem. Biophys. Res. Comm., 99:1065.

    Article  PubMed  CAS  Google Scholar 

  76. Massari, V.J., Shults, C.W., Park, C.., Tizabi, Y., Moody, T.W., Chronwall, B.M., Culver, M., and Chase, T.N., 1985, Deafferentation causes a loss of presynaptic bombesin receptors and supersensitivity of substance P receptors in the dorsal horn of the cat spinal cord, Brain Res., 343:268.

    Article  PubMed  CAS  Google Scholar 

  77. Maurer, R., and Reubi, J. C., 1985, Brain somatostatin receptor subpopulation visualized by autoradiography, Brain Res., 333:178.

    Article  PubMed  CAS  Google Scholar 

  78. Mazurek, N., Pecht, I., Teichberg, V.l., and Blumberg, S., 1981, The role of the N terminal tetrapeptide in the histamine-releasing action of substance P, Neuropharmacol., 20:1025.

    Article  CAS  Google Scholar 

  79. McGillis, J.P., Organist, M.L., and Payan, D.G., 1987, Substance P and immunoregulation, Fed. Proc, 46:196.

    PubMed  CAS  Google Scholar 

  80. Melander, T., Hokfelt, T., Nilsson, S., and Brodin, E., 1986, Visualization of galanin binding sites in the rat central nervous system, Eur. J. Pharm., 124:381.

    Article  CAS  Google Scholar 

  81. Mendeloff, A. I., 1980, Epidemiology of idiopathic inflammatory bowel disease, in: “Inflammatory Bowel Disease,”, J.B. Kirsner and R.G. Shorter, eds., Lea and Fibiger, Philadelphia.

    Google Scholar 

  82. Moody, T.W., O’Donohue, T. L., and Jacobowitz, D. M., 1981, Biochemical localization and characterization of bombesin-like peptides in discrete regions of the rat brain, Peptides, 2:75.

    Article  PubMed  CAS  Google Scholar 

  83. Mulderry, P. K., Ghatei, M. A., Spokes, R. A., Jones, P. M., Pierson, A.M., Hamic, Q.A., Kanse, S., Amara, S.G., Burrin, J.M., Legon, S., Polak, J.M., and Bloom, S.R., 1988, Differential expression of α-CGRP and β-CGRP by primary sensory neurons and enteric autonomic neurons of the rat, Neuroscience, 25:195.

    Article  PubMed  CAS  Google Scholar 

  84. Nagy, J. I., Hunt, S. P., Iversen, L. L., and Emson, P.C., 1981, Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin, Neuroscience, 6:1923.

    Article  PubMed  CAS  Google Scholar 

  85. Nilsson, J., von Euler, A.M., and Dalsgaard, C.J., 1985, Stimulation of connective tissue cell growth by substance P and substance K, Nature, 315:61.

    Article  PubMed  CAS  Google Scholar 

  86. Oku, R., Saton, M., Takagi, H., 1987, Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats, Neurosci. Lett., 74:315.

    Article  PubMed  CAS  Google Scholar 

  87. O’Morain, C., Bishop, A. E., McGregor, G. P., Levi, A.J., Bloom, S.R., Polak, J.M., and Peters, T.J., 1984, Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease, Gut, 25:56.

    Google Scholar 

  88. Orleans-Juste, D’P., Dion, S., Mizrahi, J., and Regoli, D., 1985, Effects of peptides and non-peptides on isolated arterial smooth muscles: role of endothelium, Eur. J. Pharmacol., 114:9.

    Article  PubMed  Google Scholar 

  89. Payan, D. F., Brewster, D. R., and Goetzl, E. J., 1983, Specific stimulation of human T-lymphocytes by substance P, J. Immunol., 131:1613.

    PubMed  CAS  Google Scholar 

  90. Payan, D.G., McGillis, J. P., and Goetzl, E. J., 1986, Neu-roimmunology, Adv. Immunol., 39:299.

    Article  PubMed  CAS  Google Scholar 

  91. Payan, D.G., McGillis, J.P., Organist, M.L., 1986, Binding characteristics and affinity labeling of protein consituents of the human IM-9 lymphoblast receptor for substance P, J. Biol. Chem., 261:14321.

    PubMed  CAS  Google Scholar 

  92. Pernow, B., 1983, Substance P, Pharmacol. Rev., 35:85.

    PubMed  CAS  Google Scholar 

  93. Pernow, B., 1985, Role of tachykinins in neurogenic inflammation, J. Immunol., 135:812s.

    Google Scholar 

  94. Piotrowski, W., Devoy, M.A.B., Jordan, C. C., and Foremen, J.C., 1984, The substance P receptor on rat mast cells and in human skin, Agents and Actions, 14:420.

    Article  PubMed  CAS  Google Scholar 

  95. Popper, P., Mantyh, C.R., Vigna, S.R., Maggio, J.E., and Mantyh, P.W., 1988, The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes, Peptides, 9:257.

    Article  PubMed  CAS  Google Scholar 

  96. Rainbow, T. C., Biegon, A., and Berck, D.J., 1984, Quantitative receptor autoradiography with tritium labeled ligands: comparison of biochemical and densitometric measurements, J. Neurosci. Methods, 11:231.

    Article  PubMed  CAS  Google Scholar 

  97. Reubi, J.C., Corete, R., Maurer, R., Probst, A., Palacios, J.M., 1986, Distribution of somatostatin receptors in the human brain: an autoradiographic study, Neuroscience, 18:329.

    Article  PubMed  CAS  Google Scholar 

  98. Reubi, J. C., Probst, A., Cortes, R., and Palacios, J. M., 1987, Distinct topographical localization of two somatostatin receptor subpopulations in the human cortex, Brain Res., 406:391.

    Article  PubMed  CAS  Google Scholar 

  99. Roberts, A. B., Anzano, M.A., Wakefield, L.M., Roche, N., Stern, D.F., and Sporn, M.B., 1985, Type beta transforming growth factor: a bifunctional regulator of cellular growth, Proc. Natl. Acad. Sci., 82:119.

    Article  PubMed  CAS  Google Scholar 

  100. Rosenberg, I. H., 1985, Inflammatory bowel disease, in: “Cecil Textbook of Medicine,” J.B. Wyngaarden and L.H. Smith, eds., W.B. Saunders, Philadelphia.

    Google Scholar 

  101. Rozsa, Z., Jancso, G., and Varro, V., 1984, Possibile involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog, Naunyn-Schmiedeberg’s Arch. Pharmacol., 326:352.

    Article  CAS  Google Scholar 

  102. Ruff, M. R., Wahl, S. M., and Pert, C. B., 1985, Substance P receptor-mediated Chemotaxis of human monocytes, Peptides, 6(suppl.2):107.

    Article  PubMed  CAS  Google Scholar 

  103. Schaffer, M.M., and Moody, T. W., 1986, Autoradiographic visualization of CNS receptors for vasoactive intestinal peptide, Peptides, 7:283.

    Article  Google Scholar 

  104. Schulzberg, T., Hokfelt, T., Nilsson, G., Terenius, L., Rehfeld, J.F., Brown, M., Elde, R., Goldstein, M., and Said, S., 1980, Distribution of peptide- and catecholamine containing neurons in the gastrointestinal tract of rat and guinea pig: Immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine B-hydroxylase, Neuroscience, 5:689.

    Article  Google Scholar 

  105. Sjolund, K., Schaffalitzky De Muckadell, O. B., Fahrenkrug, J., Hakanson, R., Peterson, B.G., and Sundler, F., 1983, Peptide-containing nerve fibers in the gut wall in Crohn’s disease, Gut, 24:724.

    Article  PubMed  CAS  Google Scholar 

  106. Skofitsch, G., and Jacobowitz, D. M., 1985a, Autoradiographic distribution of 125I-calcitonin gene-related peptide binding sites in the rat central nervous system, Peptides, 4:975.

    Article  Google Scholar 

  107. Skofitsch, G., and Jacobowitz, D. M., 1985b, Calcitonin gene-related peptide coexists with substance P in capsaicin-sensitive neurons and sensory ganglia of the rat, Peptides, 6:747.

    Article  PubMed  CAS  Google Scholar 

  108. Sporn, M. B., and Roberts, A. B., 1988, Peptide growth factors are multifunctional, Nature, 332:217.

    Article  PubMed  CAS  Google Scholar 

  109. Stanisz, A.M., Befus, D., and Bienenstock, J., 1986, Differential effects of vasoactive intestinal peptide, substance P and somatostatin on immunoglobulin synthesis and proliferation by lymphocytes from Peyer’s patches, mesenteric lymph nodes and spleen, J. Immunol., 136:152.

    PubMed  CAS  Google Scholar 

  110. Stephenson, J.A., Burcher, E., and Summers, R. J., 1986. Autoradiographic demonstration of endothelium-dependent [125I] Bolton-Hunter substance P binding to dog carotid artery, Eur. J. Pharmacol., 124:377.

    Article  PubMed  CAS  Google Scholar 

  111. Stricker, S., 1876, Untersuchungen uber die Gefasswurzeln dis Ischiadicus, Stitz. Ber. Kaiserl. Akad. Wiss. (Wein), 3:173.

    Google Scholar 

  112. Su, H. C., Bishop, A. E., Power, R. F., Hamada, Y., and Polak, J.M., 1987, Dual intrinsic and extrinsic origins of CGRP- and NPY-immunoreactive nerves of rat gut and pancreas, J. Neurosci., 9:2674.

    Google Scholar 

  113. Svensjo, E., Lundberg, J. M., Anggard, A., and Hokfelt, T., 1980, Substance P increase in vascular permeability and presence in the hamster cheek pouch, J. Microvascular Res., 20:38.

    Google Scholar 

  114. Tange, A., 1983, Distribution of peptide-containing endocrine cells and neurons in the gastrointestinal tract of the dog: immunohistochemical studies using antisera to somatostatin, substance P, vasoactive intestinal polypeptide, Met-enkephalin and neurotensin, Biomed. Res., 4:9.

    CAS  Google Scholar 

  115. Tschopp, F.A., Henke, H., Peterman, J.B., Tobler, P.H., Janzer, R., Hokfelt, T., Lundberg, J.M., Cuello, C., and Fischer, J.A., 1985, Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary, Proc. Natl. Acad. Sci., 82:248.

    Article  PubMed  CAS  Google Scholar 

  116. Van Dijk, A., Richards, J. G., Trzeciak, A., Gillessen, D., and Mohler, H., 1984, Cholecystokinin receptors: Biochemical demonstration and autoradiographical localization in rat brain and pancreas using [3H]cholecystokinin-8 as radioligand, J. Neurosci., 4:1021.

    PubMed  Google Scholar 

  117. Vigna, S. R., Giraud, A. S., Reeve, J. R. Jr., and Walsh, J.H., 1988, Biological activity of oxidized and reduced io-

    Google Scholar 

  118. Vigna, S. R., Mantyh, C. R., Giraud, A. S., Soll, A. H., Walsh, J.H., and Mantyh, P.W., 1987, Localization of specific binding sites for bombesin in the canine gastrointestinal tract, Gastroenterology, 93:1287.

    PubMed  CAS  Google Scholar 

  119. Wiesenfeld-Hallin, Z., Hokfelt, T., Lundberg, J. M., Forssmann, W.G., Reinecke, M., Tschopp, F.A., and Fischer, J.A., 1984, Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat, Neurosci. Letts., 199:2.

    Google Scholar 

  120. Young, W.S. III, and Kuhar, M.J., 1979, A new method for receptor autoadiography: [3H]-opioid receptors in rat brain, Brain Res., 179:255.

    Article  PubMed  CAS  Google Scholar 

  121. Zarbin, M. A., Innis, R. B., Wamsley, J. K., Snyder, S.H., and Kuhar, M.J., 1983, Autoradiographic localization of cho-lecystokinin receptors in rodent brain, J. Neurosci., 3:877.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Neurobiology Lab (151), VA Medical Center, Minneapolis, MN, USA

    P. W. Mantyh & M. Catton

  2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA

    J. E. Maggio

  3. Department of Cell Biology, Duke University Medical Center, Durham, N.C., USA

    S. R. Vigna

Authors
  1. P. W. Mantyh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Catton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Maggio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. R. Vigna
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Flinders University of South Australia, Adelaide, Australia

    Marcello Costa

  2. University of Florence, Florence, Italy

    Calogero Surrenti

  3. Fondazione Internazionale Menarini, Florence, Italy

    Sergio Gorini

  4. A. Menarini Pharmaceuticals, Florence, Italy

    Carlo Alberto Maggi  & Alberto Meli  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mantyh, P.W., Catton, M., Maggio, J.E., Vigna, S.R. (1991). Alterations in Receptors for Sensory Neuropeptides in Human Inflammatory Bowel Disease. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0744-8_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0746-2

  • Online ISBN: 978-1-4899-0744-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation