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Animal Models for Stem Cell Therapy pp 89–104Cite as

Support of Hepatic Regeneration by Trophic Factors from Liver-Derived Mesenchymal Stromal/Stem Cells

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1213))

Abstract

Mesenchymal stromal/stem cells (MSCs) have multilineage differentiation potential and as such are known to promote regeneration in response to tissue injury. However, accumulating evidence indicates that the regenerative capacity of MSCs is not via transdifferentiation but mediated by their production of trophic and other factors that promote endogenous regeneration pathways of the tissue cells. In this chapter, we provide a detailed description on how to obtain trophic factors secreted by cultured MSCs and how they can be used in small animal models. More specific, in vivo models to study the paracrine effects of MSCs on regeneration of the liver after surgical resection and/or ischemia and reperfusion injury are described.

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Author information

Authors and Affiliations

  1. Department of Surgery, Erasmus MC-University Medical Center, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands

    Jeroen de Jonge

  2. Division of Thoracic Surgery, University Hospital Bern, Bern, Switzerland

    Sean R. R. Hall

  3. Department of Surgery, Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS), Erasmus MC-University Medical Center, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands

    Suomi M. G. Fouraschen & Luc J. W. van der Laan

Authors
  1. Suomi M. G. Fouraschen
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  2. Sean R. R. Hall
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  3. Jeroen de Jonge
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  4. Luc J. W. van der Laan
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Corresponding author

Correspondence to Luc J. W. van der Laan .

Editor information

Editors and Affiliations

  1. Department of Surgery, Unviersity of Leipzig, Germany

    Bruno Christ

  2. Department of Surgery, University of Leipzig, Germany

    Jana Oerlecke

  3. Department of Surgery, University of Leipzig, Germany

    Peggy Stock

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© 2014 Springer Science+Business Media New York

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Fouraschen, S.M.G., Hall, S.R.R., de Jonge, J., van der Laan, L.J.W. (2014). Support of Hepatic Regeneration by Trophic Factors from Liver-Derived Mesenchymal Stromal/Stem Cells. In: Christ, B., Oerlecke, J., Stock, P. (eds) Animal Models for Stem Cell Therapy. Methods in Molecular Biology, vol 1213. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1453-1_9

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  • DOI: https://doi.org/10.1007/978-1-4939-1453-1_9

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1452-4

  • Online ISBN: 978-1-4939-1453-1

  • eBook Packages: Springer Protocols

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