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Calcium and Vitamin D for Bone Health in Adults

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Abstract

Low calcium and vitamin D intakes are established nutritional risk factors for osteoporosis. This chapter reviews the impact of these nutrients on calcium homeostasis and fracture risk and their role in the prevention and treatment of osteoporosis. It also reviews the impact of vitamin D on risk of falling. The calcium intake requirement is challenging to determine, and the IOM recommendations are based largely on calcium balance studies. The IOM recommends a calcium intake of 1,000–1,200 mg per day for older adults to support the preservation of bone mass. Food sources of calcium are preferred because higher intakes of calcium in supplement form have been associated with increased risk of kidney stones, and possibly also with increased risk of myocardial infarction and of death from heart disease. Vitamin D lowers fracture risk as a result of combined favorable effects on BMD, muscle performance, balance, and risk of falling. The magnitude of the risk reduction for falls and fractures with vitamin D supplementation is approximately 20 %. Daily, weekly, or monthly dosing of vitamin D3 is recommended, and high, infrequent dosing should be avoided because it increases risk of falls and fractures.

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References

  1. Ireland P, Fordtran JS. Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Investig. 1973;52(11):2672–81.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Gennari C, Agnusdei D, Nardi P, Civitelli R. Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women. J Clin Endoc Metab. 1990;71(5):1288–93.

    Article  CAS  Google Scholar 

  3. Bullamore JR, Wilkinson R, Gallagher JC, Nordin BE, Marshall DH. Effect of age on calcium absorption. Lancet. 1970;2(7672):535–7.

    Article  CAS  PubMed  Google Scholar 

  4. Ebeling PR, Sandgren ME, DiMagno EP, Lane AW, DeLuca HF, Riggs BL. Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endoc Metab. 1992;75(1):176–82.

    CAS  Google Scholar 

  5. Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med. 1990;323(13):878–83.

    Article  CAS  PubMed  Google Scholar 

  6. Garnero P, Hausherr E, Chapuy MC, Marcelli C, Grandjean H, Muller C, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study. J Bone Miner Res. 1996;11(10):1531–8.

    Article  CAS  PubMed  Google Scholar 

  7. Riis B, Thomsen K, Christiansen C. Does calcium supplementation prevent postmenopausal bone loss? A double-blind, controlled clinical study. N Engl J Med. 1987;316(4):173–7.

    Article  CAS  PubMed  Google Scholar 

  8. Elders PJ, Netelenbos JC, Lips P, van Ginkel FC, Khoe E, Leeuwenkamp OR, et al. Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age. J Clin Endoc Metab. 1991;73(3):533–40.

    Article  CAS  Google Scholar 

  9. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337(10):670–6 [see comment].

    Article  CAS  PubMed  Google Scholar 

  10. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Harris SS, Dawson-Hughes B. Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3. J Am Coll Nutr. 2002;21(4):357–62.

    Article  CAS  PubMed  Google Scholar 

  12. Krall EA, Sahyoun N, Tannenbaum S, Dallal GE, Dawson-Hughes B. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med. 1989;321(26):1777–83.

    Article  CAS  PubMed  Google Scholar 

  13. Dawson-Hughes B, Dallal GE, Krall EA, Harris S, Sokoll LJ, Falconer G. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med. 1991;115(7):505–12.

    Article  CAS  PubMed  Google Scholar 

  14. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE, Falconer G, Green CL. Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr. 1995;61(5):1140–5.

    CAS  PubMed  Google Scholar 

  15. Hunt CD, Johnson LK. Calcium requirements: new estimations for men and women by cross-sectional statistical analyses of calcium balance data from metabolic studies. Am J Clin Nutr. 2007;86(4):1054–63.

    CAS  PubMed  Google Scholar 

  16. Spencer H, Kramer L, Lesniak M, De Bartolo M, Norris C, Osis D. Calcium requirements in humans. Report of original data and a review. Clin Orthop Relat Res. 1984; (184):270–80. [Review], [84 refs]

    Google Scholar 

  17. Mackerras D, Lumley T. First- and second-year effects in trials of calcium supplementation on the loss of bone density in postmenopausal women. Bone. 1997;21(6):527–33.

    Article  CAS  PubMed  Google Scholar 

  18. Shea B, Wells G, Cranney A, Zytaruk N, Robinson V, Griffith L, et al. VII. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocr Rev. 2002;23(4):552–9.

    Article  CAS  PubMed  Google Scholar 

  19. Aloia JF, Vaswani A, Yeh JK, Ross PL, Flaster E, Dilmanian FA. Calcium supplementation with and without hormone replacement therapy to prevent postmenopausal bone loss. Ann Intern Med. 1994;120(2):97–103.

    Article  CAS  PubMed  Google Scholar 

  20. McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. J Clin Endoc Metab. 1996;81(5):1699–703.

    CAS  Google Scholar 

  21. Prince R, Devine A, Dick I, Criddle A, Kerr D, Kent N, et al. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res. 1995;10(7):1068–75.

    Article  CAS  PubMed  Google Scholar 

  22. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351(9105):805–6.

    Article  CAS  PubMed  Google Scholar 

  23. Durazo-Arvizu RA, Dawson-Hughes B, Sempos CT, Yetley EA, Looker AC, Cao G, et al. Three-phase model harmonizes estimates of the maximal suppression of parathyroid hormone by 25-hydroxyvitamin D in persons 65 years of age and older. J Nutr. 2010;140(3):595–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Aloia JF, Talwar SA, Pollack S, Feuerman M, Yeh JK. Optimal vitamin D status and serum parathyroid hormone concentrations in African American women. Am J Clin Nutr. 2006;84(3):602–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  25. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16(7):713–6.

    Article  CAS  PubMed  Google Scholar 

  26. Outila TA, Karkkainen MU, Lamberg-Allardt CJ. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am J Clin Nutr. 2001;74(2):206–10.

    CAS  PubMed  Google Scholar 

  27. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002;112(8):659–62.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Ooms ME, Roos JC, Bezemer PD, van der Vijgh WJ, Bouter LM, Lips P. Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endoc Metab. 1995;80(4):1052–8.

    CAS  Google Scholar 

  29. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Andersen H, et al. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int. 2000;66(6):419–24.

    Article  CAS  PubMed  Google Scholar 

  30. Schott GD, Wills MR. Muscle weakness in osteomalacia. Lancet. 1976;1(7960):626–9.

    Article  CAS  PubMed  Google Scholar 

  31. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Zhang Y, Karlson EW, Dawson-Hughes B. Higher 25-hydroxyvitamin D levels are associated with better lower extremity function in both active and inactive adults 60+ years of age. Am J Clin Nutr. 2004;80:752–8.

    CAS  PubMed  Google Scholar 

  32. Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab. 2007;6:6.

    Google Scholar 

  33. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int. 2011;22(3):859–71.

    CAS  PubMed  Google Scholar 

  34. Bischoff-Ferrari HA, Borchers M, Gudat F, Durmuller U, Stahelin HB, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19(2):265–9.

    Article  CAS  PubMed  Google Scholar 

  35. Wang Y, DeLuca HF. Is the vitamin d receptor found in muscle? Endocrinology. 2011;152(2):354–63.

    Article  CAS  PubMed  Google Scholar 

  36. Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. 2000;15:1113–8.

    Article  CAS  PubMed  Google Scholar 

  37. Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009;20(2):315–22.

    Article  CAS  PubMed  Google Scholar 

  38. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav EJ, Stuck AE, Theiler R, et al. Fall prevention with supplemental and alpha-hydroxylated vitamin D: a meta-analysis of randomized controlled trials. British Medical Journal. 2009;339:636–92.

    Google Scholar 

  39. Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM, et al. The effect of vitamin d on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96:2997.

    Article  CAS  PubMed  Google Scholar 

  40. Bischoff-Ferrari HA, Dawson-Hughes B, Platz A, Orav EJ, Stahelin HB, Willett WC, et al. Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med. 2010;170(9):813–20.

    Article  CAS  PubMed  Google Scholar 

  41. Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL. Effects of three monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility and muscle strength in older postmenopausal women: a randomised controlled trial. J Bone Miner Res. 2011;27:170.

    Article  Google Scholar 

  42. Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, Burckhardt P, Li R, Spiegelman D, et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr. 2007;86(6):1780–90.

    CAS  PubMed  Google Scholar 

  43. Reid IR, Bolland MJ, Grey A. Effect of calcium supplementation on hip fractures. Osteoporos Int. 2008;19(8):1119–23.

    Article  CAS  PubMed  Google Scholar 

  44. Heikinheimo RJ, Inkovaara JA, Harju EJ, Haavisto MV, Kaarela RH, Kataja JM, et al. Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int. 1992;51(2):105–10.

    Article  CAS  PubMed  Google Scholar 

  45. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003;326(7387):469 [see comment].

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. Lips P, Graafmans WC, Ooms ME, Bezemer PD, Bouter LM. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med. 1996;124(4):400–6.

    Article  CAS  PubMed  Google Scholar 

  47. Meyer HE, Smedshaug GB, Kvaavik E, Falch JA, Tverdal A, Pedersen JI. Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. J Bone Min Res. 2002;17(4):709–15.

    Article  CAS  Google Scholar 

  48. Komulainen MH, Kroger H, Tuppurainen MT, Heikkinen AM, Alhava E, Honkanen R, et al. HRT and Vit D in prevention of non-vertebral fractures in postmenopausal women; a 5 year randomized trial. Maturitas. 1998;31(1):45–54.

    Article  CAS  PubMed  Google Scholar 

  49. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40–9.

    Article  CAS  PubMed  Google Scholar 

  50. Dawson-Hughes B, Harris S, Krall EA, Dallal GE. Effect of calcium and vitamin D supplement withdrawal on bone mass in older men and women. Am J Clin Nutr. 2000;72:745–50.

    CAS  PubMed  Google Scholar 

  51. Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet. 1996;348(9041):1535–41.

    Article  CAS  PubMed  Google Scholar 

  52. Harris STM, Watts NBM, Genant HKM, McKeever CDM, Hangartner TP, Keller MMD, et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. JAMA. 1999;282(14):1344–52.

    Article  CAS  PubMed  Google Scholar 

  53. Ettinger BMD, Black DMP, Mitlak BHM, Knickerbocker RKP, Nickelsen TMD, Genant HKM, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. JAMA. 1999;282(7):637–45.

    Article  CAS  PubMed  Google Scholar 

  54. Chesnut CHI, Silverman SMD, Andriano KP, Genant HMD, Gimona AMD, Harris SMD, et al. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. Am J Med. 2000;109(4):267–76.

    Article  CAS  PubMed  Google Scholar 

  55. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19):1434–41 [comment].

    Article  CAS  PubMed  Google Scholar 

  56. IOM. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; 2011.

    Google Scholar 

  57. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993;328(12):833–8 [see comments].

    Article  CAS  PubMed  Google Scholar 

  58. Curhan GC, Willett WC, Speizer FE, Spiegelman D, Stampfer MJ. Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. Ann Intern Med. 1997;126(7):497–504 [see comments].

    Article  CAS  PubMed  Google Scholar 

  59. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354(7):669–83 [see comment] [erratum appears in N Engl J Med. 2006 Mar 9;354(10):1102].

    Article  CAS  PubMed  Google Scholar 

  60. Wallace RB, Wactawski-Wende J, O’Sullivan MJ, Larson JC, Cochrane B, Gass M, et al. Urinary tract stone occurrence in the Women’s Health Initiative (WHI) randomized clinical trial of calcium and vitamin D supplements. Am J Clin Nutr. 2011;94(1):270–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  61. Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, Ames R, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ. 2008;336(7638):262–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  62. Reid IR, Ames R, Mason B, Bolland MJ, Bacon CJ, Reid HE, et al. Effects of calcium supplementation on lipids, blood pressure, and body composition in healthy older men: a randomized controlled trial. Am J Clin Nutr. 2009;91(1):131–9.

    Article  PubMed  Google Scholar 

  63. van Mierlo LA, Arends LR, Streppel MT, Zeegers MP, Kok FJ, Grobbee DE, et al. Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens. 2006;20(8):571–80.

    Article  PubMed  Google Scholar 

  64. Samelson EJ, Booth SL, Fox CS, Tucker KL, Wang TJ, Hoffmann U, et al. Calcium intake is not associated with increased coronary artery calcification: the Framingham Study. Am J Clin Nutr. 2012;96(6):1274–80.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  65. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010;341:c3691.

    Article  PubMed Central  PubMed  Google Scholar 

  66. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005;365(9471):1621–8.

    Article  CAS  PubMed  Google Scholar 

  67. Wang L, Manson JE, Song Y, Sesso HD. Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. 2010;152(5):315–23.

    Article  PubMed  Google Scholar 

  68. Lewis JR, Calver J, Zhu K, Flicker L, Prince RL. Calcium supplementation and the risks of atherosclerotic vascular disease in older women: results of a 5-year RCT and a 4.5-year follow-up. J Bone Miner Res. 2011;26(1):35–41.

    Article  CAS  PubMed  Google Scholar 

  69. Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007;115(7):846–54.

    Article  CAS  PubMed  Google Scholar 

  70. Bolland MJ, Grey A, Gamble GD, Reid IR. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set. Am J Clin Nutr. 2011;94(4):1144–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  71. Li K, Kaaks R, Linseisen J, Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart. 2012;98(12):920–5.

    Article  CAS  PubMed  Google Scholar 

  72. Xiao Q, Murphy RA, Houston DK, Harris TB, Chow WH, Park Y. Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med. 2013;4:1–8.

    Google Scholar 

  73. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815–22.

    Article  CAS  PubMed  Google Scholar 

  74. Cipriani C, Romagnoli E, Scillitani A, Chiodini I, Clerico R, Carnevale V, et al. Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study. J Clin Endocrinol Metab. 2010;95(10):4771–7.

    Article  CAS  PubMed  Google Scholar 

  75. Harvey JA, Zobitz MM, Pak CY. Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate. J Bone Miner Res. 1988;3(3):253–8.

    Article  CAS  PubMed  Google Scholar 

  76. Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985;313(2):70–3.

    Article  CAS  PubMed  Google Scholar 

  77. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin d deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.

    Article  CAS  PubMed  Google Scholar 

  78. Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010;21:1151.

    Article  CAS  PubMed  Google Scholar 

  79. Binkley N, Gemar D, Engelke J, Gangnon R, Ramamurthy R, Krueger D, et al. Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults. J Clin Endocrinol Metab. 2011;96(4):981–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgement

This material is based on work supported by the US Department of Agriculture, under agreement number 58-1950-7-707. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the US Department of Agriculture.

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Dawson-Hughes, B. (2015). Calcium and Vitamin D for Bone Health in Adults. In: Holick, M., Nieves, J. (eds) Nutrition and Bone Health. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2001-3_14

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