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  • © 2015

Endothelial Signaling in Development and Disease

  • Comprehensive compendium of the vascular signalosome in developmental cardiovascular physiology

  • Special emphasis on the current knowledge of crosstalk between the pathways

  • Written by foremost authorities in the field of angiogenesis

  • Includes supplementary material: sn.pub/extras

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xiv
  2. Development and Differentiation of the Vascular System

    1. Front Matter

      Pages 1-1
    2. VEGF and Notch Signaling in Angiogenesis

      • Marcin Teodorczyk, Nevenka Dudvarski Stanković, Frank Bicker, Mirko HH Schmidt
      Pages 3-46
    3. Vascular Development in the Zebrafish

      • Dorien M. A. Hermkens, Henricus J. Duckers, Stefan Schulte-Merker
      Pages 47-64
    4. Pericytes in Vascular Development and Function

      • Richard Daneman, Annika Keller
      Pages 65-92
    5. Fibroblast Growth Factor Signaling in Vascular Development

      • Igor Kovacevic, Meike Hoffmeister, Stefanie Oess
      Pages 93-114
    6. Development and Differentiation of the Lymphatic Vascular System

      • Jeremiah Bernier-Latmani, Amélie Sabine, Tatiana V. Petrova
      Pages 115-133
  3. Homeostasis of the Vascular System

    1. Front Matter

      Pages 135-135
    2. Junctional Signaling in Endothelial Cells

      • Luca Bravi, Maria Grazia Lampugnani
      Pages 137-160
    3. Vascular Endothelial Growth Factor-A-Induced Vascular Permeability and Leukocyte Extravasation

      • Mia Phillipson, Gustaf Christoffersson, Lena Claesson-Welsh, Michael Welsh
      Pages 187-207
    4. The Role of Coagulation Factor Signaling in Angiogenesis and Vascular Remodeling

      • Christoph Reinhardt, Davit Manukyan, Wolfram Ruf
      Pages 233-256
  4. Pathophysiology of the Vascular System

    1. Front Matter

      Pages 257-257
    2. Axon Guidance Factors in Developmental and Pathological Angiogenesis

      • Robert Luck, Carmen Ruiz de Almodovar
      Pages 259-291
    3. The Vasculature in the Diseased Eye

      • Hans-Peter Hammes
      Pages 293-311
    4. Oxygen Signaling in Physiological and Pathological Angiogenesis

      • Anne-Theres Henze, Massimiliano Mazzone
      Pages 329-349
    5. The Pulmonary Vasculature in Chronic Obstructive Lung Disease

      • Michael Seimetz, Norbert Weissmann
      Pages 351-379
    6. Nitric Oxide Synthesis in Vascular Physiology and Pathophysiology

      • Huige Li, Ning Xia, Ulrich Förstermann
      Pages 381-397

About this book

This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Reviews

“This up-to-date and comprehensive review of endothelial biology is organized into three sections covering endothelial development, homeostasis, and pathophysiology. … This book is intended for graduate students, postdoctoral researchers, basic scientists, and clinicians with an interest in basic or translational vascular biology research. … The quality of this book is exceptional, and the work is unique. … this one is a valuable addition for vascular biologists.” (Neel A. Mansukhani, Doody’s Book Reviews, January 2016)

Editors and Affiliations

  • Microscopic Anatomy and Neurobiology Building 708, 2.Floor, R2.006, Johannes Gutenberg University School of Medicine, Mainz, Germany

    Mirko HH Schmidt

  • Institute of Neurology Building 89, 4.Floor, R402, Goethe University Frankfurt School of Medicine, Frankfurt, Germany

    Stefan Liebner

About the editors

Mirko HH Schmidt is Professor of Anatomy and Biochemistry at the Institute of Microscopic Anatomy and Neurobiology in Mainz, Germany. He received his PhD in biochemistry from the University of Lübeck, Germany and studied molecular signaling processes as a postdoc at the Hermelin Brain Tumor Center, Detroit, MI, USA and at the Institute of Biochemistry II in Frankfurt/Mainz, Germany. His research group “Molecular Signal Transduction” focuses on the degeneration of signaling pathways in the diseased brain and was located at the Institute of Neurology (Edinger Institute) in Frankfurt before moving to Mainz. Prof. Schmidt has received numerous fellowships and awards for his research on Translational Molecular Medicine.

 Stefan Liebner is a research group leader at the Institute of Neurology (Edinger Institute), Johann Wolfgang Goethe University Clinic, Frankfurt/Main, Germany. After receiving his PhD in cell biology at the Eberhard Karls University Tübingen, he investigated the role of endothelial β-catenin for vascular development at the FIRC Institute of Molecular Oncology (IFOM) Milan, Italy as a postdoctoral fellow. Dr. Liebner has received numerous fellowships and awards for his research on molecular mechanisms of blood-brain barrier development, maintenance and dysfunction. He is an active member of the International Brain Barriers Society (IBBS), and the European Vascular Biology Society (EVBM).

Bibliographic Information

  • Book Title: Endothelial Signaling in Development and Disease

  • Editors: Mirko HH Schmidt, Stefan Liebner

  • DOI: https://doi.org/10.1007/978-1-4939-2907-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2906-1Published: 09 October 2015

  • Softcover ISBN: 978-1-4939-4545-0Published: 23 August 2016

  • eBook ISBN: 978-1-4939-2907-8Published: 08 October 2015

  • Edition Number: 1

  • Number of Pages: XIV, 401

  • Number of Illustrations: 1 b/w illustrations, 48 illustrations in colour

  • Topics: Human Physiology, Cell Physiology, Hematology, Angiology, Systems Biology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access